| 產(chǎn)品編號 | bs-43601R |
| 英文名稱 | Rabbit Anti-PDGFRA antibody |
| 中文名稱 | 血小板源性生長因子受體A/PDGFRα抗體 |
| 別 名 | Platelet–dirived growth factor receptor-alpha; PDGF Receptor alpha; Alpha platelet derived growth factor receptor; CD 140a; CD140a; CD140a antigen; MGC74795; PDGF alpha chain; PDGF R alpha; PDGFR 2; PDGFR A; PDGFR alpha; PDGFR2; Platelet derived growth factor receptor 2; Platelet derived growth factor receptor alpha polypeptide; PGFRA_HUMAN. |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 117kDa |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human PDGFRA protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]. PDGFR-α是膜受體，具有酪氨酸酶的活性，與其配體PDGF結(jié)合后激活與細(xì)胞增殖有關(guān)的酶及基因。 PDGFR亦表達(dá)于上皮、內(nèi)皮細(xì)胞，前列腺、皮膚、腎小球等上皮細(xì)胞均有PDGFR表達(dá). 亦有學(xué)者報道血小板源性生長因子受體α抗體在細(xì)胞胞漿胞膜、胞核都有不同的表達(dá)還有人認(rèn)為：PDGF及其受體一般表達(dá)于浸潤病變組織的炎癥細(xì)胞附近，組織缺血損傷、腎小球高壓、免疫因素作用、炎癥細(xì)胞浸潤、實質(zhì)細(xì)胞活化等導(dǎo)致PDGFR表達(dá)增強(qiáng)。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with PDGFRA polyclonal antibody, unconjugated (bs-43601R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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