| 產(chǎn)品編號 | bs-0352R |
| 英文名稱 | Rabbit Anti-DLX4 antibody |
| 中文名稱 | DLX4抗體 |
| 別 名 | Beta protein 1; distal-less homeobox 4; DLX4; DLX4_HUMAN; DLX7; DLX8; Homeobox protein DLX-4; Homeobox protein DLX-7; Homeobox protein DLX-8; Homeobox protein DLX4. |
| 研究領(lǐng)域 | 染色質(zhì)和核信號 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 26kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DLX4: 151-240/240 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]. Function: May play a role in determining the production of hemoglobin S. May act as a repressor. Subcellular Location: Nucleus (Potential). Tissue Specificity: Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver. Similarity: Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: Q92988 Gene ID: 1748 Database links: Entrez Gene: 1748 Human Entrez Gene: 13394 Mouse Omim: 601911 Human SwissProt: Q92988 Human SwissProt: P70436 Mouse Unigene: 591167 Human Unigene: 439766 Mouse DLX4基因的表達異常與乳腺癌、結(jié)腸癌以及白血病的發(fā)生有關(guān).與AML-急性髓系白血病有一定的相關(guān)性，DLX4 在急性髓系白血病有高表達，在急性淋巴細(xì)胞白血病中無表達，可作為AML的一種分子標(biāo)志，用于兩者的鑒別參考。 |
