| 產(chǎn)品編號 | bs-0064R |
| 英文名稱 | Rabbit Anti-Neurokinin 1 Receptor antibody |
| 中文名稱 | P物質(zhì)受體抗體 |
| 別 名 | Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1. NK1-R |
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Specific References (6) | bs-0064R has been referenced in 6 publications.
[IF=7.727] Jinbo Li. et al. Low dose shikonin and anthracyclines coloaded liposomes induce robust immunogenetic cell death for synergistic chemo-immunotherapy. J Control Release. 2021 Jul;335:306 IHC ; Mouse.
[IF=3.889] Jimei Zhang. et al. Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor. PHARM BIOL. 2023;61(1):449-458 IF ; Human.
[IF=3.877] Zhang et al. Effects of Neuropeptide Substance P on Proliferation and β-Cell Differentiation of Adult Pancreatic Ductal Cells. (2018) Front.Neurosci. 12:807 IHC ; Rat.
[IF=1.966] Tian L et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2019 Nov 25. IHC-P ; rat&mink.
[IF=0] 任緒瑩, et al. "小半夏湯對水貂嘔吐模型作用機(jī)制的研究." Acta Neuropharmacologica 1.3 (2011). WB ; Other Species.
[IF=0] 楊玉玲, et al. "姜辣素輔助昂丹司瓊對順鉑所致大鼠異嗜行為的抑制作用."?世界華人消化雜志?19.10 (2011): 1034-1039. IHC-F ; Rat.
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| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse,Pig,Cow,Dog,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPR: 2-50/407 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Subunit: Interacts with ARRB1 Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25103 Gene ID: 6869 Database links: Entrez Gene: 6869 Human Entrez Gene: 21336 Mouse Omim: 162323 Human SwissProt: P25103 Human SwissProt: P30548 Mouse Unigene: 633301 Human Unigene: 8055 Mouse Unigene: 89609 Rat 此抗體與大、小鼠、及豚鼠均有交叉反應(yīng)。P物質(zhì)是由11個氨基酸組成的多肽，主要分布于感覺神經(jīng)纖維、后根神經(jīng)節(jié)和脊髓后角，作為重要的神經(jīng)遞質(zhì)或調(diào)制因子參與傷害性刺激的傳遞，該遞質(zhì)與突觸后膜上P物質(zhì)受體結(jié)合，將痛沖動傳入中樞，產(chǎn)生疼痛反應(yīng)。 P物質(zhì)與神經(jīng)源性炎癥、瘙癢及疼痛的產(chǎn)生有關(guān)，通過刺激肥大細(xì)胞釋放組織胺、緩激肽及前列腺素等致炎、致敏、致痛物質(zhì)，引起一系列病理反應(yīng)，P物質(zhì)除作為傷害性信息的信使外，本身又為炎癥介質(zhì)。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human SH-SY5Y cell lysates
Lane 2: Human U87MG cell lysates
Lane 3: Human U251 cell lysates
Lane 4: Human HeLa cell lysates
Primary: Anti-Neurokinin 1 Receptor (bs-0064R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kDa
Observed band size: 50 kDa
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