| 產(chǎn)品編號 | bs-1110R |
| 英文名稱 | Rabbit Anti-SP7/Osterix antibody |
| 中文名稱 | 成骨相關(guān)轉(zhuǎn)錄因子抗體 |
| 別 名 | SP7_HUMAN; Transcription factor Sp7; OSX; Zinc finger protein osterix; Sp7 transcription factor; Osterix; |
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Specific References (30) | bs-1110R has been referenced in 30 publications.
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| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45kDa |
| 檢測分子量 | 45-50/56 |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SP7: 271-380/431 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010] Function: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). Subunit: Interacts with NO66; the interaction is direct and inhibits transcription activator activity. Subcellular Location: Nucleus. Tissue Specificity: Osteoblast/chondrocyte specific. DISEASE: Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. SWISS: Q8TDD2 Gene ID: 121340 Database links: Entrez Gene: 121340 Human Entrez Gene: 170574 Mouse Omim: 606633 Human SwissProt: Q8TDD2 Human SwissProt: Q5RM08 Mouse SwissProt: Q8VI67 Mouse
Osterix成骨相關(guān)轉(zhuǎn)錄因子是一種具有鋅指基序結(jié)構(gòu)域的轉(zhuǎn)錄因子，在體內(nèi)的表達(dá)對成骨細(xì)胞具有特異性。該蛋白只在發(fā)育的骨組織中特異性表達(dá)，是成骨細(xì)胞分化和骨形成過程中所必需的轉(zhuǎn)錄因子。骨髓基質(zhì)干細(xì)胞分化為表達(dá)典型的成骨性標(biāo)志基因的成骨細(xì)胞需要OSX的調(diào)控。 |
| 產(chǎn)品圖片 |
Sample:Spinal cord (Mouse) Lysate at 40 ug
Primary: Anti-Osterix(bs-1110R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45kD
Observed band size: 50kD
Sample:
Lane 1: Mouse Embryo tissue lysates
Lane 2: Mouse Testis tissue lysates
Lane 3: Mouse Cerebrum tissue lysates
Primary: Anti-SP7/Osterix (bs-1110R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kDa
Observed band size: 47 kDa
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