| 產(chǎn)品編號(hào) | bs-0874R |
| 英文名稱 | Rabbit Anti-DEK antibody |
| 中文名稱 | DEK癌基因結(jié)合蛋白 |
| 別 名 | D6S231E; Dek; DEK gene; DEK oncogene; DEK oncogene DNA binding; DNA binding; DEK_HUMAN; OTTHUMP00000039357; Protein DEK. |
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Specific References (1) | bs-0874R has been referenced in 1 publications.
[IF=2.42] Yang, Y., Wu, M., Geng, Y., Liu, X., Yang, Y., Chen, X., ... & Xie, L. (2017). Roles of DEK in the endometrium of mice in early pregnancy. Gene. WB, IHC-P ; Mouse.
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| 研究領(lǐng)域 | 染色質(zhì)和核信號(hào) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DEK: 101-200/315 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The DEK gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA which then induces positive supercoils into closed circular DNA, and is also involved during mRNA processing in splice site selection. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. Function: Involved in chromatin organization. Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA. Subcellular Location: Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. Tissue Specificity: Ubiquitous. Expressed at relatively high levels. Post-translational modifications: Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA. DISEASE: Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene. Similarity: Contains 1 SAP domain. SWISS: P35659 Gene ID: 7913 Database links: Entrez Gene: 7913 Human Entrez Gene: 110052 Mouse Omim: 125264 Human SwissProt: P35659 Human SwissProt: Q7TNV0 Mouse Unigene: 484813 Human Unigene: 131150 Mouse Unigene: 25099 Rat DEK癌基因結(jié)合蛋白，主要參與DNA核轉(zhuǎn)錄。目前多用于白血病及急性髓系白血病的研究。 |
