| 產(chǎn)品編號 | bs-2606R |
| 英文名稱 | Rabbit Anti-IL17RA antibody |
| 中文名稱 | 白介素17受體抗體 |
| 別 名 | Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; hIL-17R; IL-17R; MGC10262; CD217; CDw217; IL17 RECEPTOR; IL17FR; AW538159; I17RA_HUMAN. |
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Specific References (6) | bs-2606R has been referenced in 6 publications.
[IF=8.469] Miyajima, Hisao. et al. Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice. Cell Death Dis. 2021 Aug;12(8):1-11 IHC ; Mouse.
[IF=4.546] Hyo In Kim. et al. Gardenia Jasminoides Ameliorates Antibiotic-Associated Aggravation of DNCB-Induced Atopic Dermatitis by Restoring the Intestinal Microbiome Profile. Nutrients. 2021 Apr;13(4):1349 WB ; Mouse.
[IF=2.302] Sun B et al.
The interleukin-17 G-197A polymorphism is associated with cyclosporine metabolism and transplant rejection in liver transplant recipients. Pharmacogenomics. 2019 Feb 25. WB ; Human.
[IF=1.48] Tang, Wei?Jing, et al. "Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma." Oncology Letters. IHC-P ; Human.
[IF=1.39] Tang et al. Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma. (2017) Oncol.Lett. 14:561-568 IHC-P ; Human.
[IF=0] Bockerstett et al. Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis. (2018) Cell.Mol.Gastroenterol.Hepatol. 5:678-690.e1 IF ; Mouse.
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| 研究領(lǐng)域 | 細胞膜受體 細胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 92kDa |
| 細胞定位 | 細胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-17RA: 201-300/866 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. [provided by RefSeq] Function: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Widely expressed. Post-translational modifications: Glycosylated. DISEASE: Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Similarity: Contains 1 SEFIR domain. SWISS: Q96F46 Gene ID: 23765 Database links: Entrez Gene: 23765 Human Entrez Gene: 16172 Mouse Omim: 605461 Human SwissProt: Q96F46 Human SwissProt: Q60943 Mouse Unigene: 48353 Human Unigene: 4481 Mouse |
| 產(chǎn)品圖片 |
Sample:
Raw264.7(Mouse) Cell Lysate at 30 ug
Primary: Anti- IL17A Receptor (bs-2606R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 92 kD
Observed band size: 120 kD
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