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Rabbit Anti-Phospho-HSL (Ser660)  antibody (bs-3358R)  
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產(chǎn)品編號(hào) bs-3358R
英文名稱 Rabbit Anti-Phospho-HSL (Ser660)  antibody
中文名稱 磷酸化荷爾蒙敏感脂肪酶抗體
別    名 Hormone sensitive lipase; Hormone sensitive lipase testicular isoform; HSL; LHS; Lipase hormone sensitive; LIPE.  
Specific References  (1)     |     bs-3358R has been referenced in 1 publications.
[IF=4.486] Chengqian Li. et al. Mutation of the novel acetylation site at K414R of BECN1 is involved in adipocyte differentiation and lipolysis. 2021 Jun 04  WB ;  Human.  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 心血管  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse,Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 83kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from mouse HSL around the phosphorylation site of Ser660: SK(p-S)HE 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Subcellular Location:
Cell membrane. Membrane, caveola. Cytoplasm,bcytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.

Post-translational modifications:
Phosphorylation by AMPK may block translocation to lipid droplets.

Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.

SWISS:
P54310

Gene ID:
16890

Database links:

Entrez Gene: 3991 Human

Entrez Gene: 16890 Mouse

Entrez Gene: 25330 Rat

Omim: 151750 Human

SwissProt: Q05469 Human

SwissProt: Q6NSL7 Human

SwissProt: P54310 Mouse

SwissProt: P15304 Rat

Unigene: 656980 Human

Unigene: 158548 Mouse

Unigene: 333679 Mouse

Unigene: 10566 Rat



HSL又稱:敏感性甘油三酯脂肪酶,在脂肪動(dòng)員中,脂肪細(xì)胞內(nèi)激素敏感性甘油三酯脂肪酶(HSL)起決定性作用,它是脂肪分解的限速酶,稱為激素敏感性脂肪酶。腎上腺素、去甲腎上腺素、胰高血糖素等激活HSL促進(jìn)脂肪動(dòng)員;胰島素,前列腺素E及煙酸等抑制HSL,抑制脂肪的動(dòng)員。
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