| 產(chǎn)品編號 | bs-2348R |
| 英文名稱 | Rabbit Anti-Natriuretic Peptide Receptor B antibody |
| 中文名稱 | 利鈉肽受體B抗體 |
| 別 名 | AMDM; ANP B; ANP-B; ANPB; ANPR-B; ANPRB; ANPRB_HUMAN; Atrial natriuretic peptide B type receptor; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor B; Atrial natriuretic peptide receptor B precursor; Atrial natriuretic peptide receptor type B; Atrionatriuretic peptide receptor B; GC B; GC-B; GCB; Guanylate cyclase B; GUC 2B; GUC2B; GUCY 2B; GUCY2B; Natriuretic peptide receptor B; Natriuretic peptide receptor B/guanylate cyclase B; NPR 2; NPR B; NPR-B; NPR2; NPRB; NPRBi; OTTHUMP00000045390. |
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Specific References (1) | bs-2348R has been referenced in 1 publications.
[IF=2.43] Li, Ping, et al. "CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan." World Journal of Gastroenterology: WJG 21.5 (2015): 1518. WB ; Rat.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Pig,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 117kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NPR-B: 101-200/1047 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand binding domain, a single membrane spanning region, and intracellularly a protein kinase homology domain), a helical hinge region involved in oligomerization, and a carboxyl terminal guanylyl cyclase catalytic domain. NPR2 is the primary receptor for C type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Subcellular Location: Membrane; Single-pass type I membrane protein. Post-translational modifications: Phosphorylation of the protein kinase-like domain is required for full activation by CNP. DISEASE: Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth. Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain. SWISS: P20594 Gene ID: 4882 Database links: Entrez Gene: 4882 Human Entrez Gene: 230103 Mouse Omim: 108961 Human SwissProt: P20594 Human SwissProt: Q6VVW5 Mouse Unigene: 78518 Human
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