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Rabbit Anti-SOD3  antibody (bs-3895R)  
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產品編號 bs-3895R
英文名稱 Rabbit Anti-SOD3  antibody
中文名稱 超氧化物歧化酶3抗體
別    名 EC-SOD; Superoxide Dismutase 3; ALS; ALS1; Cu/Zn superoxide dismutase; EC SOD; Extracellular superoxide dismutase [Cu Zn]; Extracellular superoxide dismutase; Extracellular superoxide dismutase precursor; Homodimer; Indophenoloxidase A; IPOA; Mn superoxide dismutase; SOD 3; SOD; SOD soluble; SOD2; SOD3; Superoxide dismutase 3 extracellular; Superoxide dismutase cystolic; SODE_HUMAN; extracellular superoxide dismutase isoform 1.   
Specific References  (4)     |     bs-3895R has been referenced in 4 publications.
[IF=5.81] Xinyue Chang. et al. The Protective Effect of Trichilia catigua A. Juss. on DEHP-Induced Reproductive System Damage in Male Mice. Front Pharmacol. 2022; 13: 832789  IHC ;  Mouse.  
[IF=5.195] Xin Zhao. et al. Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3. EUR J PHARMACOL. 2022 Jun;:175115  IHC ;  Rat.  
[IF=3.221] Kobayashi T et al. The characteristic regulation of gene expression Lbp and Sod3 in peri‐implant connective tissue of rats. J Biomed Mater Res A. 2019 Nov 12.  IHC-P ;  Rat.  
[IF=0] SUKADANA IM et al. The Intake of Inocarpus Fagiferus Fosb Stem Bark N-Buthanol Extract Caused the Increase Expression of Sod-2 and Sod-3 Aortic Endhotelial Cells of Hypercholesterolemia Rats. Biomedical and Pharmacology Journal.2017,?10(4):1773-1777?·  WB ;  Rat.  
研究領域 腫瘤  細胞生物  免疫學  染色質和核信號  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24kDa
細胞定位 細胞外基質 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SOD3: 227-240/240 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]

Function:
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Subunit:
Homotetramer.

Subcellular Location:
Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Tissue Specificity:
Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

Similarity:
Belongs to the Cu-Zn superoxide dismutase family.

SWISS:
P08294

Gene ID:
6649

Database links:

Entrez Gene: 6649 Human

Entrez Gene: 20657 Mouse

Entrez Gene: 25352 Rat

Omim: 185490 Human

SwissProt: P08294 Human

SwissProt: O09164 Mouse

SwissProt: Q08420 Rat

Unigene: 2420 Human

Unigene: 2407 Mouse

Unigene: 10358 Rat



產品圖片
Sample: Placenta (Mouse) Lysate at 40 ug Primary: Anti-SOD3(bs-3895R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24kD Observed band size: 27kD
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