| 產(chǎn)品編號(hào) | bs-7772R |
| 英文名稱 | Rabbit Anti-SEPT14 antibody |
| 中文名稱 | 細(xì)胞分化蛋白SEPT14抗體 |
| 別 名 | SEPT14; SEPT 14; SEP14_HUMAN; Septin-14; Septin 14; Septin14; FLJ44060. |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞周期蛋白 細(xì)胞分化 細(xì)胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SEPT14: 351-432/432 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Septin 14, also known as SEPT14, is a 432 amino acid protein that belongs to the septin family. The highly conserved septin family of GTP-binding cytoskeletal proteins is implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis and other cellular functions. Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. Septin 14 has a GTPase domain followed by a C-terminal coiled-coil domain characteristic of group II septins. Septin 14 interacted with all septins except those that are members of its phylogenetic cluster, including itself. Septin 14 shares highest identity (67%) with Septin 10. Expressed in testis and more weakly in fetal liver, tonsil and thymus, the Septin 14 protein is not detected in testicular cancer or other normal or cancer cell lines. The Septin 14 gene is conserved in chimpanzee, dog, cow, mouse and rat, and maps to human chromosome 7p11.2. Function: SEPT14 is a filament-forming cytoskeletal GTPase. It may play a role in cytokinesis. Subunit: Septins polymerize into heterooligomeric proteincomplexes that form filaments, and can associate with cellularmembranes, actin filaments and microtubules. GTPase activity isrequired for filament formation (By similarity). Interacts withSEPT9. Subcellular Location: Cytoplasm. Tissue Specificity: Testis-specific. Similarity: Belongs to the septin family. SWISS: Q6ZU15 Gene ID: 346288 Database links: Entrez Gene: 346288 Human Omim: 612140 Human SwissProt: Q6ZU15 Human Unigene: 453629 Human SEPTIN(SEPT)家族是細(xì)胞骨架蛋白的一種，具有GTPase的活性。經(jīng)研究發(fā)現(xiàn)，SEPT參與細(xì)胞的分裂、細(xì)胞膜的運(yùn)輸以及構(gòu)成細(xì)胞骨架。 |
| 產(chǎn)品圖片 |
Sample:
Testis (Mouse) Lysate at 40 ug
Primary: Anti- SEPT14 (bs-7772R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 50 kD
|
