| 產(chǎn)品編號(hào) | bs-8291R |
| 英文名稱(chēng) | Rabbit Anti-DPY19L2 antibody |
| 中文名稱(chēng) | DPY19L2蛋白抗體 |
| 別 名 | D19L2_HUMAN; Probable C-mannosyltransferase DPY19L2; dpy 19 like 2; dpy 19 like 2 (C. elegans); Dpy 19 like protein 2; Dpy-19-like protein 2; dpy19; FLJ32949; FLJ36166; Protein dpy 19 homolog 2; Protein dpy-19 homolog 2. |
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Specific References (4) | bs-8291R has been referenced in 4 publications.
[IF=11.043] Chunyu Liu. et al. Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models. AM J HUM GENET. 2023 Feb 15 WB ; Human,Monkey.
[IF=9.621] Lixiao Zhou. et al. Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles. Environ Int. 2022 May;163:107220 WB ; Mouse.
[IF=6.918] Li Yaqian. et al. Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects. Hum Reprod. 2021 Nov;: IF ; Mouse,Human.
[IF=5.589] WB ; mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 發(fā)育生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 87kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DPY19L2: 101-200/758 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011] Function: Required during spermatogenesis for sperm head elongation and acrosome formation. Subunit: Membrane; Multi-pass membrane protein (Potential). Subcellular Location: Involvement in disease：Defects in DPY19L2 are a cause of globozoospermia (GLOBZOOS) . An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome. In the most severe cases the acrosome is totally absent. Globozoospermia is also characterized by abnormal nuclear shape as well as abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of GLOBZOOS. Tissue Specificity: Widely expressed with high expression in testis. DISEASE: Defects in DPY19L2 are the cause of spermatogenic failure type 9 (SPGF9) [MIM:613958]. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of SPGF9. Similarity: Belongs to the dpy-19 family. SWISS: Q6NUT2 Gene ID: 283417 Database links: Entrez Gene: 283417 Human Entrez Gene: 320752 Mouse SwissProt: Q6NUT2 Human SwissProt: P0CW70 Mouse Unigene: 533644 Human |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Testis tissue lysates
Primary: Anti-DPY19L2 (bs-8291R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 87 kDa
Observed band size: 77 kDa
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