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Rabbit Anti-SCUBE1  antibody (bs-9903R)  
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產(chǎn)品編號 bs-9903R
英文名稱 Rabbit Anti-SCUBE1  antibody
中文名稱 新型血小板相關(guān)血管內(nèi)皮分泌蛋白SCUBE1抗體
別    名 SCUB1_HUMAN; SCUBE 1; SCUBE1; Signal peptide, CUB and EGF-like domain-containing protein 1.  
研究領(lǐng)域 心血管  內(nèi)皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 105kDa
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCUBE1: 451-550/988 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.

Function:
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.

Subunit:
Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3.

Subcellular Location:
Secreted. Cell membrane.

Tissue Specificity:
Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferrred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.

Post-translational modifications:
N-glycosylated.
Could be proteolytically cleaved to release a smaller active fragment.

Similarity:
Contains 1 CUB domain.
Contains 9 EGF-like domains.

SWISS:
Q8IWY4

Gene ID:
80274

Database links:

Entrez Gene: 80274 Human

Entrez Gene: 64706 Mouse

Entrez Gene: 315174 Rat

Omim: 611746 Human

SwissProt: Q8IWY4 Human

SwissProt: Q6NZL8 Mouse

Unigene: 133995 Human

Unigene: 40393 Mouse



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