| 產(chǎn)品編號 | bs-11865R |
| 英文名稱 | Rabbit Anti-KLF7 antibody |
| 中文名稱 | KLF樣轉(zhuǎn)錄因子7抗體 |
| 別 名 | KLF7; KLF7_HUMAN; Krueppel like factor 7; Krueppel-like factor 7; Kruppel like factor 7 ; Ubiquitous krueppel like factor; Ubiquitous krueppel-like factor; UKLF. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞分化 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 33kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KLF7: 131-210/302 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
KLF7 is a transcriptional activator that belongs to the Krüppel C2H2-type zinc finger protein family. KLF7 targets promotor regions bearing CACCC elements in order to regulate transcription. It is believed that KLF7 is an important element for regulation of differentiation and the development of nervous systems. Specifically, increased expression of KLF7 is associated with neuronal precursors exiting the cell cycle and beginning to differentiate. Overexpression of KLF7 can lead to cell cycle arrest and a decrease in DNA synthesis. Also, KLF7 is thought to regulate the expression of Trk A, the receptor for nerve growth factor, which is required for the normal growth and maturation of neurons. KLF7 is a widely expressed protein with highest expression found in brain and nervous tissue. Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. SWISS: O75840 Gene ID: 8609 Database links: Entrez Gene: 8609 Human Entrez Gene: 93691 Mouse Omim: 604865 Human SwissProt: O75840 Human SwissProt: Q99JB0 Mouse Unigene: 471221 Human Unigene: 29466 Mouse Unigene: 458200 Mouse Unigene: 102325 Rat |
| 產(chǎn)品圖片 |
Sample: Spinal code (Mouse) Lysate at 40 ug
Primary: Anti-KLF7 (bs-11865R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 33 kD
Observed band size: 33 kD
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