| 產(chǎn)品編號 | bs-12012R |
| 英文名稱 | Rabbit Anti-MGLUR3 antibody |
| 中文名稱 | 代謝型谷氨酸受體-3抗體 |
| 別 名 | G protein coupled receptor family C group 1 member C; GLUR 3; GLUR3; GLUR3; Glutamate metabotropic receptor 3; Glutamate receptor metabotropic 3; GPRC1C; GRM 3; GRM3; GRM3_HUMAN; Metabotropic glutamate receptor 3; Metabotropic glutamate receptor 3 precursor; mGlu 3; MGlu3; MGlu3; MGLUR 3; MGLUR3. |
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Specific References (1) | bs-12012R has been referenced in 1 publications.
[IF=2.666] X Zhou et al. Modulating NMDA receptors to treat MK-801-induced schizophrenic cognition deficit: effects of clozapine combining with PQQ treatment and possible mechanisms of action. BMC Psychiatry. 2020 Mar 6;20(1):106. WB ; rat.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,Flow-Cyt=5μg/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 96kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Metabotropic Glutamate Receptor 3: 365-460/879 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Subunit: nteracts with GRASP Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 3 family. SWISS: Q14832 Gene ID: 2913 Database links: Entrez Gene: 2913 Human Entrez Gene: 108069 Mouse Omim: 601115 Human SwissProt: Q14832 Human SwissProt: Q9QYS2 Mouse Unigene: 590575 Human Unigene: 318966 Mouse Unigene: 41715 Rat |
| 產(chǎn)品圖片 |
Sample:
Cerebral cortex (Mouse) Lysate at 40 ug
Primary: Anti-MGLUR3 (bs-12012R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 96 kD
Observed band size: 116 kD
Sample:
Hippocampus (Mouse) Lysate at 40 ug
Primary: Anti-MGLUR3 (bs-12012R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 96 kD
Observed band size: 116 kD
Sample:
Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti-MGLUR3 (bs-12012R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 96 kD
Observed band size: 116 kD
Blank control: Mouse Liver Cells(fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice). Primary Antibody: Rabbit Anti- MGLUR3/PE Conjugated antibody (bs-12012R-PE), Dilution: 5μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/PE(orange) ,used under the same conditions.
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