| 產(chǎn)品編號 | bs-13151R |
| 英文名稱 | Rabbit Anti-FCGRT antibody |
| 中文名稱 | IgG-Fc片斷受體轉(zhuǎn)運蛋白α抗體 |
| 別 名 | IgG receptor FcRn large subunit p51; Fc fragment of IgG, receptor transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRN, alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor, intestinal, heavy chain; Neonatal Fc receptor; FCGRN_HUMAN. |
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Specific References (1) | bs-13151R has been referenced in 1 publications.
[IF=1.64] Zhang, Wang-Dong, et al. "Localization of neonatal Fc receptor for IgG in aggregated lymphoid nodules area in abomasum of Bactrian camels (Camelus bactrianus) of different ages." BMC Veterinary Research 12.1 (2016): 237. IHC-P ; Others.
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| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 細胞膜受體 血管內(nèi)皮細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Sheep,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,Flow-Cyt=3μg/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 37kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FCGRT/FcRn: 51-150/365 <Extracellular> |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn ? chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins. Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Subunit: FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). Subcellular Location: Cell membrane. Similarity: Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SWISS: P55899 Gene ID: 2217 Database links: Entrez Gene: 2217 Human Omim: 601437 Human SwissProt: P55899 Human Unigene: 111903 Human |
| 產(chǎn)品圖片 |
Sample: bladder (Mouse)Lysate at 40 ug
Primary: Anti-FCGRT(bs-13151R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38kD
Observed band size: 38 kD
Blank control(blue): U-87MG(fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit AntiFCGRT antibody(bs-13151R), Dilution: 3μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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