| 產(chǎn)品編號 | bs-13992R |
| 英文名稱 | Rabbit Anti-COREST antibody |
| 中文名稱 | COREST蛋白抗體 |
| 別 名 | COREST; KIAA0071; Protein CoREST; RCOR; RCOR1; RCOR1_HUMAN; REST corepressor 1. |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號 神經(jīng)生物學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 53kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COREST: 201-300/482 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] Function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Subcellular Location: Nucleus. Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Phosphorylated by HSV-1 protein kinases in case of infection. Similarity: Belongs to the CoREST family. Contains 1 ELM2 domain. Contains 2 SANT domains. SWISS: Q9UKL0 Gene ID: 23186 Database links: Entrez Gene: 23186 Human Entrez Gene: 217864 Mouse Omim: 607675 Human SwissProt: Q9UKL0 Human SwissProt: Q8CFE3 Mouse Unigene: 510521 Human Unigene: 23808 Mouse |
