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Rabbit Anti-NKD2  antibody (bs-19262R)  
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產(chǎn)品編號 bs-19262R
英文名稱 Rabbit Anti-NKD2  antibody
中文名稱 NKD2蛋白抗體
別    名 hNkd2; Naked 2; Naked-2; nkd2; NKD2_HUMAN; Protein naked cuticle homolog 2.  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導(dǎo)  干細胞  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50kDa
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NKD2: 321-420/451 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

Subcellular Location:
Cell membrane. Cytoplasm. Cytoplasmic vesicle.

Tissue Specificity:
Expressed in kidney, lung, pancreas and spleen.

Post-translational modifications:
Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25.

Similarity:
Belongs to the NKD family.
Contains 1 EF-hand domain.

SWISS:
Q969F2

Gene ID:
85409

Database links:

Entrez Gene: 85409 Human

Omim: 607852 Human

SwissProt: Q969F2 Human

Unigene: 240951 Human



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