| 產(chǎn)品編號(hào) | bs-22318R |
| 英文名稱 | Rabbit Anti-Cyclin A1 antibody |
| 中文名稱 | 周期素A1蛋白抗體 |
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Specific References (2) | bs-22318R has been referenced in 2 publications.
[IF=4.638] Li Li. et al. LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells. BMC CANCER. 2022 Dec;22(1):1-19 WB ; Bovine.
[IF=2.13] Yusong Ge. et al. L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway. J ANIM PHYSIOL AN N. 2022 May 26 WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細(xì)胞周期蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Sheep,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 51kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cyclin A1 : 391-465/465 |
| 亞 型 | IgG |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Cyclin A1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A1 is expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. It binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Cyclin A1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. Subcellular Location: Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER. Similarity: Belongs to the cyclin family. Cyclin AB subfamily. SWISS: P78396 Gene ID: 8900 Database links: Entrez Gene: 8900 Human Entrez Gene: 12427 Mouse Omim: 604036 Human SwissProt: P78396 Human SwissProt: Q61456 Mouse Unigene: 417050 Human Unigene: 4815 Mouse |
| 產(chǎn)品圖片 |
Sample:
Testis (Mouse) Lysate at 40 ug
Testis (Rat) Lysate at 40 ug
Primary: Anti-Cyclin A1 (bs-22318R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52’54 kD
Observed band size: 52 kD
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