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Rabbit Anti-Chk1  antibody (bsm-60743R)  
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產(chǎn)品編號 bsm-60743R
英文名稱 Rabbit Anti-Chk1  antibody
中文名稱 細(xì)胞周期檢測點激酶1重組兔單抗
別    名 Cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1; Checkpoint kinase 1; Checkpoint kinase 1 homolog (S. pombe); CHEK 1; CHEK-1; CHEK1; Chk 1; CHK1 checkpoint homolog (S. pombe); EC 2.7.11.1; rad27; Serine/threonine protein kinase Chk1; Serine/threonine-protein kinase CHK1; STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae); C85740; CHK1_HUMAN.  
研究領(lǐng)域 腫瘤  染色質(zhì)和核信號  細(xì)胞周期蛋白  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Recombinant
交叉反應(yīng) Human (predicted: Mouse,Rat)
產(chǎn)品應(yīng)用 WB=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 54kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Chk1 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 50mM Tris-Glycine (pH7.4), 0.15M NaCl, 40% Glycerol, 0.02% Proclin300 and 0.05% BSA.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011].

SWISS:
O14757

Gene ID:
1111

Database links:

Entrez Gene: 1111 Human

Entrez Gene: 12649 Mouse

Entrez Gene: 140583 Rat

Omim: 603078 Human

SwissProt: O14757 Human

SwissProt: O35280 Mouse

SwissProt: Q91ZN7 Rat

Unigene: 24529 Human

Unigene: 16753 Mouse

Unigene: 33267 Rat



產(chǎn)品圖片
Sample: Lane 1: Human A431 cell lysates Lane 2: Human HeLa cell lysates Lane 3: Human MOLT4 cell lysates Lane 4: Human MCF-7 cell lysates Lane 5: Human U-2 OS cell lysates Primary: Anti-Chk1 (bsm-60743R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kDa Observed band size: 50 kDa
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