| 產(chǎn)品編號 | V4201 |
| 英文名稱 | PGII |
| 中文名稱 | 胃蛋白酶原C單克隆抗體 |
| 別 名 | PEPC_HUMAN; Gastricsin; EC:3.4.23.3; Pepsinogen C; PEPC; PGC; progastricsin; |
| 克 隆 號 | 3D5 |
| 理論分子量 | 42kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Lyophilized or Liquid |
| 緩 沖 液 | PBS (pH7.4). |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq]. Function: Hydrolyzes a variety of proteins. Subcellular Location: Secreted. Similarity: Belongs to the peptidase A1 family. SWISS: P20142 Gene ID: 5225 Database links: Entrez Gene: 5225 Human Omim: 169740 Human SwissProt: P20142 Human Unigene: 1867 Human Unigene: 9735 Rat 胃蛋白酶原C(PG-C)主要用于胃癌及其癌前病變易感性的關(guān)系。 |
