| 產(chǎn)品編號(hào) | W6101 |
| 英文名稱(chēng) | Alpha 1 microglobulin |
| 中文名稱(chēng) | α1微球蛋白抗體 |
| 別 名 | alpha 1 Microglobulin; Alpha 1 microglobulin/bikunin precursor; Alpha-1 microglycoprotein; AMBP; AMBP_HUMAN; Bikunin; Complex-forming glycoprotein heterogeneous in charge; EDC1; Growth inhibiting protein 19; HCP; HI 30; HI-30; HI30; IATIL; Inter alpha trypsin inhibitor light chain; ITI; ITI LC; ITI-LC; ITIL; ITILC; Kunitz domain; Plasma protein; Protein HC; Proteinase inhibitor; Trypstatin; Uronic-acid-rich protein; UTI;a1-MG; α1-MG; |
| 理論分子量 | 37kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 緩 沖 液 | 0.01M PBS (pH7.4) with 0.02% Proclin300. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
This gene encodes a complex glycoprotein secreted inplasma. The precursor is proteolytically processed into distinctfunctioning proteins: alpha-1-microglobulin, which belongs to thesuperfamily of lipocalin transport proteins and may play a role inthe regulation of inflammatory processes, and bikunin, which is aurinary trypsin inhibitor belonging to the superfamily ofKunitz-type protease inhibitors and plays an important role in manyphysiological and pathological processes. This gene is located onchromosome 9 in a cluster of lipocalin genes. Function: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin,and lysosomal granulocytic elastase. Inhibits calcium oxalatecrystallization. Trypstatin is a trypsin inhibitor Subunit: I-alpha-I plasma protease inhibitors are assembled fromone or two heavy chains (H1, H2 or H3) and one light chain,bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 andbikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.Alpha-1-microglobulin occurs as a monomer and also in complexeswith IgA and albumin. Alpha-1-microglobulin interacts with FN1.Trypstatin is a monomer and also occurs as a complex with tryptasein mast cells (By similarity). Alpha-1-microglobulin and bikunininteract (via SH3 domain) with HEV ORF3 protein. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver and secreted in plasma.Alpha-1-microglobulin occurs in many physiological fluids includingplasma, urine, and cerebrospinal fluid. Inter-alpha-trypsininhibitor is present in plasma and urine. Post-translational modifications: The precursor is proteolytically processed into separatelyfunctioning proteins. 3-hydroxykynurenine, an oxidized tryptophan metabolite thatis common in biological fluids, reacts with Cys-53, Lys-111,Lys-137, and Lys-149 to form heterogeneous polycyclic chromophoresincluding hydroxanthommatin. The reaction by alpha-1-microglobulinis autocatalytic; the human protein forms chromophore even whenexpressed in insect and bacterial cells. The chromophore can reactwith accessible cysteines forming non-reducible thioethercross-links with other molecules of alpha-1-microglobulin or withother proteins such as Ig alpha-1 chain C region 'Cys-352'. Heavy chains are interlinked with bikunin via a chondroitin4-sulfate bridge to the their C-terminal aspartate (By similarity). N- and O-glycosylated. N-glycan heterogeneity at Asn-115:Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5(minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of theglycosaminoglycan, chondroitin sulfate, at Ser-215 allowscross-linking between the three polypeptide chains. Similarity: In the N-terminal section; belongs to the calycinsuperfamily. Lipocalin family. Contains 2 BPTI/Kunitz inhibitor domains. SWISS: P02760 Gene ID: 259 Database links: Entrez Gene: 259 Human Omim: 176870 Human SwissProt: P02760 Human Unigene: 436911 Human Unigene: 18721 Rat |
