| 產(chǎn)品編號 |
V5902-Gold |
| 英文名稱 |
MMP9
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| 中文名稱 |
Gold標記的基質(zhì)金屬蛋白酶-9單克隆抗體 |
| 別 名 |
Matrix metalloproteinase-9 precursor; MMP-9; MMP9; MMP 9; 92 kDa type IV; Collagenase; 92 kDa gelatinase; Gelatinase B; GELB; MMP9_HUMAN; 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG-4B; CLG4B; Collagenase Type 4 beta; Collagenase Type-4 beta; Collagenase type IV 92 KD; Collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase 92 KD; Gelatinase beta; Gelatinase-beta; GelatinaseB; GELB; Macrophage gelatinase; MANDP2; Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix Metalloproteinase 9; Type V collagenase. |
| 緩 沖 液 |
0.01M PBS (pH7.4). |
| 保存條件 |
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
bs-7059P is one synthetic peptide derived from human MMP-9.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].
MMP9亦稱IV型膠原酶或明膠酶B，其主要功能為降解IV型膠原。因而它在腫瘤細胞突破基底膜屏障和浸潤轉(zhuǎn)移中起重要作用。
目前主要用于各種惡性腫瘤(如乳腺癌、胃腸道癌、卵巢癌、膀胱癌等)中的基底膜檢測與轉(zhuǎn)移浸潤的研究。細胞外基質(zhì)在維持正常組織結(jié)構(gòu)與功能以及細胞生長和分化過程中起重要作用。細胞外基質(zhì)動態(tài)平衡的失調(diào)與腫瘤細胞侵襲、轉(zhuǎn)移和復(fù)發(fā)密切相關(guān)，基質(zhì)金屬蛋白酶(MMP9)是細胞外基質(zhì)的降解酶，可降解Ⅳ、Ⅴ、Ⅸ、Ⅺ型膠原，在腫瘤的浸潤、轉(zhuǎn)移過程中起重要作用，近年為腫瘤研究的熱點。
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