| 產(chǎn)品編號 |
IHC0353R |
| 英文名稱 |
Rat CD44 Ready-To-Use IHC Kit
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| 中文名稱 |
大鼠CD44即用型免疫組化試劑盒 |
| 別 名 |
AU023126, AW121933, AW146109, CD44, CDW44, CSPG8, ECMR-III, HCELL, HERMES, HUTCH-I, IN, LHR, Ly-24, MC56, MDU2, MDU3, MIC4, Pgp-1, Pgp1 |
| 保存條件 |
Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.
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| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded rat thymus tissue slide using IHC0353R (Rat CD44 Kit).
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