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Rabbit Anti-Fbx32  antibody (bsm-54451R)  
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產(chǎn)品編號(hào) bsm-54451R
英文名稱 Rabbit Anti-Fbx32  antibody
中文名稱 泛素蛋白連接酶重組兔單抗
別    名 Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.  
Specific References  (6)     |     bsm-54451R has been referenced in 6 publications.
[IF=8.713] Zhao-Bo Luo. et al. Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis. ELIFE. 2023; 12: e81858  WB ;  Mouse.  
[IF=6.228] Xuzhu Lin. et al. Undercarboxylated osteocalcin and ibandronate combination ameliorates hindlimb immobilization-induced muscle wasting. J PHYSIOL-LONDON. 2023 Apr;:  WB ;  Human.  
[IF=5.085] Shuang-Yan Chang. et al. miR-320 regulates myogenesis by targeting growth factor receptor-bound protein-2 and ameliorates myotubes atrophy. INT J BIOCHEM CELL B. 2022 Jun;147:106212  WB ;  Mouse.  
[IF=4.755] Zhang Lijiao. et al. Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke–induced model of chronic obstructive pulmonary disease. FRONT PHYSIOL. 2022 Aug;0:1600  WB ;  Mouse.  
[IF=4.171] Xunyu Wei. et al. Zanthoxylum Alkylamides Ameliorate Protein Metabolism in Type 2 Diabetes Mellitus Rats by Regulating Multiple Signaling Pathways. 2021 Mar 11  WB ;  Rat.  
[IF=2.893] Lijiao Zhang. et al. Myostatin/HIF2α-Mediated Ferroptosis is Involved in Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. INT J CHRONIC OBSTR. 2022 Sep;17:2383-2399  WB ;  Mouse.  
研究領(lǐng)域 細(xì)胞生物  干細(xì)胞  泛素  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號(hào) 2A3
交叉反應(yīng) Mouse,Rat (predicted: Human)
產(chǎn)品應(yīng)用 WB=1:2000-20000,ICC/IF=1:20-100
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human Fbx32: 1-200/355 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antib
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.

Function:
Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

Subunit:
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus.

Tissue Specificity:
Specifically expressed in cardiac and skeletal muscle.

Similarity:
Contains 1 F-box domain.

SWISS:
Q969P5

Gene ID:
114907

Database links:

Entrez Gene: 513776 Cow

Entrez Gene: 114907 Human

Entrez Gene: 67731 Mouse

Entrez Gene: Q2KHT6 Pig

Entrez Gene: 171043 Rat

Omim: 606604 Human

SwissProt: Q2KHT6 Cow

SwissProt: Q969P5 Human

SwissProt: Q9CPU7 Mouse

SwissProt: Q1A730 Pig

SwissProt: Q91Z62 Rat

Unigene: 403933 Human

Unigene: 292042 Mouse

Unigene: 72619 Rat



產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with Fbx32 monoclonal antibody, unconjugated (bsm-54451R) at 1:10000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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