来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
少妇粉嫩小泬喷水视频WWW|永久免费精品精品永久-夜色
Rabbit Anti-Pokemon/ZBTB7A/PE-Cy7 Conjugated antibody (bs-0891R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@73327.net
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0891R-PE-Cy7
英文名稱1 Rabbit Anti-Pokemon/ZBTB7A/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的撲克蒙蛋白抗體
別    名 Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; FBI-1; FBI1; HIV-1 1st-binding protein 1; Leukemia/lymphoma related factor; LRF; Pokemon; TIP21; TTF-I interacting peptide 21; ZBTB7; ZBTB7A; Zinc finger and BTB domain-containing protein 7A; ZBT7A_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  微生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)菌及病毒  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pokemon
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.

Function:
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.

Subunit:
Interacts with BCL6.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).

Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.

Database links:

Entrez Gene: 51341 Human

Entrez Gene: 16969 Mouse

Omim: 605878 Human

SwissProt: O95365 Human

SwissProt: O88939 Mouse

Unigene: 591384 Human

Unigene: 20920 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Pokemon(7APOK Erythroid Myeloid Ontogenic factor)能夠控制將正常細(xì)胞變成癌細(xì)胞所需的途徑,Pokemon蛋白是轉(zhuǎn)錄因子蛋白家族的一員,并且在人類癌癥中發(fā)生了突變。另外Pokemon蛋白作為轉(zhuǎn)錄因子參與一些細(xì)胞基因轉(zhuǎn)錄的調(diào)節(jié),并在細(xì)胞分化過(guò)程中發(fā)揮著關(guān)鍵、多效性的功能。近來(lái)發(fā)現(xiàn),Poke-mon在致癌轉(zhuǎn)化過(guò)程中發(fā)揮著至關(guān)重要的功能,并與腫瘤的發(fā)生密切相關(guān)。
這種蛋白很可能在實(shí)質(zhì)腫瘤中處于重要地位,還有學(xué)者認(rèn)為:Pokemon在一定類型的B細(xì)胞和T細(xì)胞淋巴瘤中水平非常高,并發(fā)現(xiàn)具有高水平Pokemon蛋白表達(dá)對(duì)腫瘤惡性程度改變更大。
主要定位于細(xì)胞核。
撲克蒙”蛋白又稱“波克曼”蛋白。
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
av无码久久久久久不卡网站| 高傲人妻女教师的沉沦长篇| 亚洲综合图色40P| 免费A级毛片无码| 欧美一区二区三区亚洲九色| 欧美性受xxxx黑人xyx性爽| 日韩人妻精品一区二区三区视频| 亚洲一区二区三区av高清| 蜜臀AV在线播放| SAO货撅起你的贱屁股来| 无码精品人妻一区二区三区人妻斩| 日日噜噜噜夜夜爽爽狠狠| 久久精品免视看国产成人明星| 亚洲老熟女@tubeumtv| 一本一道波多野结衣AV中文| 国产SP调教打屁股视频网站| 久久精品国产亚洲AV成人| 日本精品久久久久一区二区三区 | 国产美女被遭强高潮免费网站| 国产精品99无码一区二区| 中文字幕成人无码| 国产AV无码专区亚洲AV毛片搜| 精品人妻无码一区二区三区,| 久久国产精品一区二区久久| 最近中文字幕高清中文字幕无| av天堂男人资源网| 欧美老妇大p毛茸茸| 69久久夜色精品国产69| 日进去了啊内射视频| 日本在线有码电影网站| 日本不卡毛片一区二区| AV免费网站在线观看| 色ww色色ww色色| 亚洲av福利院在线观看| 久久人人爽人人爽人人片AV高清 | 自偷自拍另类小说| 国产精品毛片一区二区三区| 欧洲色综合天天在线影院| 夫妻久久久久久久久了| 少妇无套内谢久久久久| 国模冰莲自慰肥美胞极品人体图|