来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
欧美极品JIZZHD欧美|国产69精品久久久久9999不|99精品久久99久久久
Rabbit Anti-Adenovirus 5 E1A/PE Conjugated antibody (bs-6136R-PE)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@73327.net
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-6136R-PE
英文名稱(chēng)1 Rabbit Anti-Adenovirus 5 E1A/PE Conjugated antibody
中文名稱(chēng) PE標(biāo)記的腺病毒早期E1A蛋白抗體
別    名 Adenovirus early E1A protein; Control protein E1A; E1A; Early E1A protein; Human adenovirus type 5; Human adenovirus C; pfam02703; E1A_ADE05.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 免疫學(xué)  細(xì)菌及病毒  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105.

Function:
E1A protein has both transforming and trans-activating activities. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Disrupts the function of host retinoblastoma protein RB1/pRb and isoform early E1A 26 kDa protein stabilizes TP53, which are key regulators of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif.

Subunit:
Interacts with host UBE2I; this interaction interferes with polySUMOylation (Probable). Interaction with host RB1 induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Interacts with host ATF7; the interaction enhances ATF7-mediated viral transactivation activity which requires the zinc binding domains of both proteins. Isoform early E1A 32 kDa protein and isoform early E1A 26 kDa protein interact (via N-terminus) with CUL1 and E3 ubiquitin ligase RBX1; these interactions inhibit RBX1-CUL1-dependent elongation reaction of ubiquitin chains. Interacts (via N-terminus) with the SCF(FBW7) complex; this interaction results in inhibition of the ubiquitin ligase activity of the SCF(FBW7) complex, ubiquitination of SCF(FBW7) target proteins being diminished. Interacts (via PXLXP motif) with host ZMYND11/BS69 (via MYND-type zinc finger); this interaction inhibits E1A mediated transactivation.

Subcellular Location:
Host nucleus (Potential).

Similarity:
Belongs to the adenoviridae E1A protein family.

Database links:
UniProtKB/Swiss-Prot: P03255.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品视频一区| 真实14初次破初视频在线播放| 亚洲欧美一区二区综合精品| 风流老熟女一区二区三区| 亚洲AV无码专区国产不卡顿 | 特级毛片WWW| 国产一区二区久久久久久久免费| 国产亚洲色婷婷久久99精品| 疯狂的交换小雅小姿1~6| 香港经典A毛片免费观看变态| 99热在线观看| 波多野结衣一区二区视频| 国产sm调教视频在线观看 | 男女无遮挡XX00动态图120秒| 亚洲男人天堂| 久久久久国色AV免费观看性色 | 欧美黑人粗暴多交高潮水最多| 厨房一次又一次的索要| 欧美大片一区二区三区| 97AV| 人妻 日韩 欧美 综合 制服| 亚洲乱码一区二区三区在线观看| 狠狠在啪线香蕉777视频| 欧美老妇交ZOZO| 人妻在卧室被老板疯狂进入| 熟妇少妇一区二区三区| 一区二区乱子伦在线播放| 中出内射后入在线观看| 91精品国产高久久久久久婷婷| 国产美女遭强被高潮网站| 人人妻人人澡人人爽欧美一区| 又大又粗又爽免费视频A片| 国产精品偷伦视频免费观看了| 女生迈开腿让男生打扑克| 69视频在线看中文在线观看不卡| 久久无码中文字幕久久无| 亚洲欧美日韩综合视频| 成av人片一区二区三区久久| 无码人妻精品一区二区三区久久久 | 婷婷色香合缴缴情av第三区| 色婷婷av一区二区三区不卡|