来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产精品免费看久久久无码|中文字幕在线观看
Rabbit Anti-Adenovirus 5 E1A/PE-Cy3 Conjugated antibody (bs-6136R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@73327.net
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6136R-PE-Cy3
英文名稱1 Rabbit Anti-Adenovirus 5 E1A/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的腺病毒早期E1A蛋白抗體
別    名 Adenovirus early E1A protein; Control protein E1A; E1A; Early E1A protein; Human adenovirus type 5; Human adenovirus C; pfam02703; E1A_ADE05.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  細(xì)菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105.

Function:
E1A protein has both transforming and trans-activating activities. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Disrupts the function of host retinoblastoma protein RB1/pRb and isoform early E1A 26 kDa protein stabilizes TP53, which are key regulators of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif.

Subunit:
Interacts with host UBE2I; this interaction interferes with polySUMOylation (Probable). Interaction with host RB1 induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Interacts with host ATF7; the interaction enhances ATF7-mediated viral transactivation activity which requires the zinc binding domains of both proteins. Isoform early E1A 32 kDa protein and isoform early E1A 26 kDa protein interact (via N-terminus) with CUL1 and E3 ubiquitin ligase RBX1; these interactions inhibit RBX1-CUL1-dependent elongation reaction of ubiquitin chains. Interacts (via N-terminus) with the SCF(FBW7) complex; this interaction results in inhibition of the ubiquitin ligase activity of the SCF(FBW7) complex, ubiquitination of SCF(FBW7) target proteins being diminished. Interacts (via PXLXP motif) with host ZMYND11/BS69 (via MYND-type zinc finger); this interaction inhibits E1A mediated transactivation.

Subcellular Location:
Host nucleus (Potential).

Similarity:
Belongs to the adenoviridae E1A protein family.

Database links:
UniProtKB/Swiss-Prot: P03255.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
又湿又紧又大又爽A视频| 久久精品AⅤ无码中文字字| 国产精品免费久久蜜色av| 操大爷影院| 男人的好免费观看直播| 久久99国产精品二区护士| 日本精品欧美一区二区| 久久久久女人精品毛片| 呻吟丰满一区二区三区| 国产V综合V亚洲欧美久久| 国产性生交XXXXX免费| 女人18毛片A级毛片免费视频| 亚洲av在线观看| 中文字幕无码AV波多野吉衣| 久久精品中文字幕| 无码专区AAAAAA免费视频| 人妻天天爽夜夜爽精品视频| 一区二区三区亚洲黄片免费看| 久久久av一区二区三区| 精品国产制服丝袜高跟| 午夜亚洲国产理论片中文| 8AV国产精品爽爽ⅤA在线观看| 日韩欧美97中文字幕| 亚洲国产精品无码中文字| 9999久久久久老熟妇二区| 艳妇乳肉豪妇荡乳| 国产一级a在线观看免费| 老子午夜精品无码| 娇小萝被两个黑人用半米长| 我把五十老女人弄高潮了| 在线网中文娱乐网| 玖玖爱A片资源在线观看| 精品人妻无码一区二区色欲产成人| 亚洲国产一区二区三区在线观看 | 日本无码视频在线观看| 精品亚洲国产成人AV制服| 无人在线观看完整免费版视频| 少妇被躁爽到高潮无码人狍大战| 男女猛烈拍拍拍无挡视频免费| 亚精区区一区区二免费| 亚洲老熟女@tubeumtv|