来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
GOGOGO免费视频观看|女人爽到喷水的视频大全|丰满老熟好大BBB
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-SH2D1A/Biotin Conjugated antibody (bs-9873R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-9873R-Bio
英文名稱1 Rabbit Anti-SH2D1A/Biotin Conjugated antibody
中文名稱 生物素標記的信號傳導T淋巴細胞活化相關(guān)蛋白抗體
別    名 SH2 domain protein 1A; DSHP; Duncan disease SH2 protein; SAP; Signaling lymphocyte activation molecule associated protein; SLAM associated protein; T cell signal transduction molecule SAP; SH21A_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學  信號轉(zhuǎn)導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SH2D1A/SAP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
產(chǎn)品介紹 background:
SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).

Function:
Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

Subunit:
Interacts with NTRK1, NTRK2 and NTRK3 (By similarity). Interacts with CD84, CD244, LY9, SLAMF1 and FYN.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.

DISEASE:
Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.

Similarity:
Contains 1 SH2 domain.

Database links:

Entrez Gene: 4068 Human

Entrez Gene: 20400 Mouse

Entrez Gene: 501502 Rat

Omim: 300490 Human

SwissProt: O60880 Human

SwissProt: O88890 Mouse

SwissProt: B2RZ59 Rat

Unigene: 349094 Human

Unigene: 441197 Mouse

Unigene: 12605 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
人妻精品久久久久中文字幕69| 久久18禁高潮出水呻吟娇喘| 精品久久久久久久久中文字幕永久| 日韩一区二区麻豆国产| 亚洲精品国产精品国自产观看 | 黑人巨茎和中国美女视频| 国产精品毛片更新无码| 天天干天天日| 朋友的妈妈在线观看| 小鲜肉吃小鲜肉的大LOGO| 欧美日韩国产综合专区| 99视频日本区一区二| 少妇高潮流白浆在线观看| 杨门女将之浪荡合集| 91欧美一区二区三区| 久久久久久国产精品免费免费男同| 忘忧草影院在线| 亚洲AV成人无码久久精品老人| 小箩莉末发育娇小性色XXXX| 欧美疯狂做受XXXXX高潮| 国产美女极度色诱视频WWW | 国产又粗又长又硬免费视频| 国产一区二区三区| 日韩av一区二区在线播放| 亚洲色欲一区二区三区在线观看| 少妇性饥渴无码A区免费| 又污又爽又黄的网站| 啊灬啊别停灬用力啊黑人| 人妻人妻与人妻人妻AV| 久久精品夜色国产亚洲av| 国产精品普通话对白在线视频| 欧美人与动欧交视频| 欧洲美女与动交ZOZ0Z| 手机在线免费无码视频| 色综合99久久久无码国产精品| 成熟丰满熟妇高潮XXXXX视频| 亚洲欧美一区二区三区在线| 国产成人久久精品亚洲| 欧美人妻精品一区二区三区99| 亚洲国产精品一区久久 | 久久久久久久久久女黄久久久久久|