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Rabbit Anti-TCN2/AP Conjugated antibody (bs-9919R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-9919R-AP
英文名稱1 Rabbit Anti-TCN2/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的轉(zhuǎn)鈷胺素蛋白2抗體
別    名 Macrocytic anemia; TC; TC II; TC-2; TC2; TCII; TCN 2; TCO2_HUMAN; Transcobalamin 2; Transcobalamin II; Transcobalamin II; macrocytic anemia; Transcobalamin-2; Vitamin B12 binding protein 2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCN2/Transcobalamin II
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Transcobalamin I (TCI) and Transcobalamin II (TCII) are secreted proteins belonging to the eukaryotic cobalamin transport proteins family and also to the vitamin B12-binding protein family. The genes encoding these proteins map to chromosome 11q11-q12 and 22q12.2, respectively. Transcobalamin I is a constituent of secondary granules in neutrophils, while Transcobalamin II binds cobalamin and mediates its transport into cells. These plasma proteins are expressed in various tissues and secretions.

Function:
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

Subcellular Location:
Secreted.

DISEASE:
Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.

Similarity:
Belongs to the eukaryotic cobalamin transport proteins family.

Database links:

Entrez Gene: 6948 Human

Omim: 275350 Human

SwissProt: 275350 Human

SwissProt: P20062 Human

Unigene: 417948 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Involvement in disease;Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.
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