| 產(chǎn)品編號 | bs-11408R-BF488 |
| 英文名稱1 | Rabbit Anti-ACTHR/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的促腎上腺皮質(zhì)激素受體 |
| 別 名 | ACTH receptor; ACTH-R; ACTHR; ACTHR_HUMAN; Adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; Corticotropin receptor; MC2 receptor; MC2-R; MC2R; Melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin 2 receptor; Melanocortin receptor 2. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MC2 receptor (67-105aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Function: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Subunit: Interacts with FALP/MRAP. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Melanocytes and corticoadrenal tissue. DISEASE: Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 4158 Human Entrez Gene: 17200 Mouse Omim: 607397 Human SwissProt: Q01718 Human SwissProt: Q64326 Mouse Unigene: 248144 Human Unigene: 426053 Mouse Unigene: 92460 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
