| 產(chǎn)品編號(hào) | bs-11467R-BF488 |
| 英文名稱1 | Rabbit Anti-Neuron navigator 1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的神經(jīng)細(xì)胞引領(lǐng)蛋白Nav1抗體 |
| 別 名 | Nav 1; Nav1; POMFIL 3; POMFIL3; Pore membrane and/or filament interacting like protein 3; Protein Steerin 1; Protein Steerin1; Steerin 1; Steerin1; unc-53 homolog 1; DKFZp781D0314; FLJ12560; FLJ14203; mNav1; NAV1_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 神經(jīng)生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 202kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neuron navigator 1 (1426-1475aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 產(chǎn)品介紹 |
background: Neuron navigator 1 is a 1877 amino acid cytoplasmic protein that is involved in neuronal migration. Neuron navigtor 1 is widely expressed at low levels, though highest expression is found in both adult and fetal nervous tissue. Through interaction with tubulin, Neuron navigator 1 associates with a subset of mirotubule plus ends present in the growth cone. Overexpression of Neuron navigator 1 leads to microtubule bundling, whereas a reduction of its levels causes loss of directionality in the migration of pontine cell leading processes. There are seven isoforms of Neuron navigator 1 that are produced as a result of alternative splicing events. Function: The development of the nervous system (NS) requires the coordinated migration of multiple waves of neurons and subsequent processes of neurite maturation, both involving selective guidance mechanisms. In Caenorhabditis elegans, unc-53 codes for a new multidomain protein involved in the directional migration of a subset of cells. We describe here the first functional characterization of the mouse homologue, mouse Neuron navigator 1 (mNAV1) expression is primarily restricted to the CNS during development. mNAV1 is a microtubules associated protein. The abolition of mNAV1 causes loss of directionality in the leading processes of pontine-migrating cells, providing evidence for a role of mNAV1 in mediating (Netrin1-induced) directional migration. Subunit: Interacts with tubulin Subcellular Location: Cytoplasm, cytoskeleton. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones. Tissue Specificity: Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta. Similarity: Belongs to the Nav/unc-53 family. Database links: UniProtKB/Swiss-Prot: Q8NEY1.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
