產品編號 |
bs-11526R-BF555 |
英文名稱1 |
Rabbit Anti-GALP/BF555 Conjugated antibody
|
中文名稱 |
BF555標記的神經甘丙肽樣肽GALP抗體 |
別 名 |
Alarin; Alarin splice variant; Galanin like peptide; Galanin like peptide precursor protein; GALP precursor protein; GALP_HUMAN. |
規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
說 明 書 |
100ul
|
研究領域 |
腫瘤 心血管 細胞生物 發(fā)育生物學 神經生物學 生長因子和激素 G蛋白偶聯(lián)受體 G蛋白信號 |
抗體來源 |
Rabbit |
克隆類型 |
Polyclonal |
交叉反應 |
(predicted: Human, )
|
產品應用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
分 子 量 |
6kDa |
性 狀 |
Lyophilized or Liquid |
濃 度 |
1mg/ml |
免 疫 原 |
KLH conjugated synthetic peptide derived from human GALP (25-84aa) |
亞 型 |
IgG |
純化方法 |
affinity purified by Protein A |
儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產品介紹 |
background: This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, may have vasoactive properties and serve as a marker for neuroblastic tumors.[provided by RefSeq, Mar 2009].
Function: This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, may have vasoactive properties and serve as a marker for neuroblastic tumors. Isoform 2 exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effect which does not appear to be mediated via GALR1 or GALR2.
Subcellular Location: Secreted.
Tissue Specificity: Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.
Similarity: Belongs to the galanin family.
Database links:
Entrez Gene: 85569 Human
Omim: 611178 Human
SwissProt: Q9UBC7 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
|