来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
99国产精品国产精品九九|国产精品无码免费播放
Rabbit Anti-Aurora A/PE Conjugated antibody (bs-2749R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2749R-PE
英文名稱1 Rabbit Anti-Aurora A/PE Conjugated antibody
中文名稱 PE標(biāo)記的有絲分裂激酶A抗體
別    名 Aurora A (phospho-Thr288); p-Aurora A(T288); AIK; ARK-1; ARK1; AURA; AURKA; Aurora 2; Aurora A; Aurora A; Aurora Family Kinase 1; aurora kinase A; Aurora Related Kinase 1; Aurora-related kinase 1; Aurora/IPL1 Like Kinase; Aurora/IPL1 Related Kinase 1; Aurora/IPL1-related kinase 1; AURORA2; AYK1; BRAK; Breast Tumor Amplified Kinase; Breast tumor-amplified kinase; BTAK; hARK1; IAK; IPL1 Aurora Related Kinase 1; IPL1 Related Kinase; MGC34538; OTTHUMP00000031340; OTTHUMP00000031341; OTTHUMP00000031342; OTTHUMP00000031343; OTTHUMP00000031344; OTTHUMP00000031345; OTTHUMP00000166071; OTTHUMP00000166072; PPP1R47; Protein phosphatase 1, regulatory subunit 47; Serine/threonine kinase 15; Serine/threonine kinase 6; Serine/threonine kinase; Serine/threonine kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; STK15; STK6; STK6_HUMAN; STK7.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  細(xì)胞周期蛋白  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Auroa A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.

Function:
Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.

Subunit:
Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Post-translational modifications:
Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Phosphorylated upon DNA damage, probably by ATM or ATR. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Aurora subfamily. Contains 1 protein kinase domain.

Database links:

Entrez Gene: 6790 Human

Entrez Gene: 20878 Mouse

Omim: 603072 Human

SwissProt: O14965 Human

SwissProt: P97477 Mouse

Unigene: 250822 Human

Unigene: 249363 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細(xì)胞的有絲分裂是生物體最基本的生命活動過程,能將復(fù)制的基因組精確地分配到下一代子細(xì)胞中,在長期的生物進化過程中,生物體形成了一整套完善的監(jiān)測機制以確保遺傳物質(zhì)精確地分配到子細(xì)胞中。
Aurora激酶(極光激酶)是細(xì)胞有絲分裂調(diào)控網(wǎng)絡(luò)中的一類重要的絲氨酸/蘇氨酸激酶,Aurora酪氨酸激酶B也是絲氨酸/蘇氨酸激酶家族成員之一,目前分為aurora A,B及C。
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
无码熟熟妇丰满人妻啪啪| 少妇扒开粉嫩小泬视频| 波多野洁衣| 欧美在线播放一区二区三区| 亚洲国产精品国自产拍AV| 特级毛片WWW| 99国产精品国产精品九九| 极品少妇XXXXⅩ另类| 99精品日韩欧美在线观看| 亚洲性欧美se视频在线| 中国浓毛少妇毛茸茸| 沈阳熟妇28厘米大战黑人| 青青青在线香蕉免费国产| 国产欧美一区二区三区在线不卡| 国产色欲色欲社WWW| 天天躁日日躁狠狠躁2018| 91亚洲国产成人久久| 午夜视频试看3分钟| 久久伊人69日韩精品| 亚洲国产精品久久久久爰色欲| 麻豆亚洲AV成人无码久久精品| 6080YYY午夜理论片中无码| 久久久久久三区二区精品| 成人免费不卡在线视频| 俄罗斯女人大P毛茸茸| 久久久久久久久欧美精品| 人人做人人爽国产视| 国产精品普通话对白在线视频| 人妻在卧室被老板疯狂进入| B站禁止转播404入口| 午夜影院1000在线免费观看| 色哟哟在线观看国产精品| 国产一区二区三区在线播放不卡域名 | 少妇愉情理伦片丰满丰满午夜| 欧美大片一区二区三区| 精品人妻无码区二区三区| 蜜臀av国产精品久久久久| 国产无遮挡A片又黄又爽| 一级白丝美女久久久久| 99久久久国产精品免费蜜臀| 日韩亚洲国产精品久久高清线|