来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯(lián)系我們
国产精品免费久久蜜色av|人妻无码av不卡中文字幕
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-MAPKAPK2 (Thr222)/FITC Conjugated antibody (bs-3261R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3261R-FITC
英文名稱1 Rabbit Anti-Phospho-MAPKAPK2 (Thr222)/FITC Conjugated antibody
中文名稱 FITC標記的磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
別    名 MAPKAP Kinase 2 (phospho S222); p-MAPKAP Kinase 2 (phospho S222); 3PK; AA960234; MAP kinase activated protein kinase 2; MAP kinase activated protein kinase 3; MAPK activated protein kinase 2; MAPK activated protein kinase 3; MAPKAP kinase 2; MAPKAP kinase 3; MK2; MK3; MAPK2_HUMAN; OTTHUMP00000034531; Rps6kc1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 免疫學  信號轉導  細胞凋亡  轉錄調節(jié)因子  激酶和磷酸酶  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat, Monkey,  (predicted: Human, Dog, Cow, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MAPKAPK2 around the phosphorylation site of Thr222
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.

Function:
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Subunit:
Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface. Interacts with PHC2.

Subcellular Location:
Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.

Tissue Specificity:
Expressed in all tissues examined.

Post-translational modifications:
Sumoylation inhibits the protein kinase activity.
Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-334.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 9261 Human

Entrez Gene: 17164 Mouse

Entrez Gene: 289014 Rat

Omim: 602006 Human

SwissProt: P49137 Human

SwissProt: P49138 Mouse

Unigene: 643566 Human

Unigene: 713747 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.73327.net 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
无码人妻久久一区二区三区不卡| 久久久精品视频地址| 少妇高潮毛片免费看| 日韩不卡的一区二区三区视频| 久久丫精品国产亚洲AV| 国产精品久久久久久三级精品 | 中日韩V无码中文字幕| 四虎国产精品亚洲永久免费| 99精品在线免费视频| 偷窥自拍88titieham88| 日本A级床戏大尺度在线观看| 欧美日韩国产精品| 中国女人学生69XXXX| 日本动漫在线| 国产美女自慰在线观看| 我强行与岳的性关系| 日产一区二区| 欧美亚洲综合另类一区| 国产日产欧产精品精品首页| 国产成年无码久久久久毛片| 免费看又黄又无码的网站| 欧美日韩大片一区二区| 精品国产自在久久现线拍| 亚洲午夜国产精品无码| 色欲AV永久无码精品无码蜜桃| 色综合久久精品亚洲国产| 特级毛片爽WWW免费版| 欧美成人性生活在线观看| 荫蒂每天被三个男人添视频| 漂亮人妻被黑人久久精品噜噜噜激激 | 不许人间见白头| 日欧一片内射VA在线影院| 日韩无码专区| 国产色秀视频在线播放| 无码孕妇孕交在线观看| 最新亚洲人成无码网WWW电影| 久久夜色精品国产噜噜亚洲av| 性欧美se| 国产精品Ⅴ无码大片在线看| 1717国产精品视频| 亚洲HAIRY多毛PICS大全|