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Rabbit Anti-Phospho-PPIG (Ser376)/PE-Cy5 Conjugated antibody (bs-3461R-PE-Cy5)
訂購(gòu)熱線(xiàn):400-901-9800
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技術(shù)支持:techsupport@73327.net
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-3461R-PE-Cy5
英文名稱(chēng)1 Rabbit Anti-Phospho-PPIG (Ser376)/PE-Cy5 Conjugated antibody
中文名稱(chēng) PE-Cy5標(biāo)記的磷酸化親環(huán)蛋白(親環(huán)素)PPIG抗體
別    名 CARS cyclophilin; CARS Cyp; CASP 10; CASP10; Clk associating RS cyclophilin; Cyclophilin G; CyclophilinG; CYP; MGC133241; Peptidyl prolyl cis trans isomerase G; Peptidyl prolyl isomerase G; Peptidylprolyl isomerase G (cyclophilin G); Peptidylprolyl isomerase G; PPIase G; Rotamase G; RotamaseG; PPIG_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 89kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PPIG around the phosphorylation site of Ser376 [VS(p-S)GE]
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing.

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

Subunit:
Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.

Subcellular Location:
Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 PPIase cyclophilin-type domain.

Database links:

Entrez Gene: 9360 Human

Entrez Gene: 228005 Mouse

Entrez Gene: 83624 Rat

Omim: 606093 Human

SwissProt: Q13427 Human

SwissProt: A2AR02 Mouse

SwissProt: O55035 Rat

Unigene: 727580 Human

Unigene: 11815 Mouse

Unigene: 474951 Mouse

Unigene: 10898 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肽基脯氨?;?lè)串悩?gòu)酶,廣泛存在于各種組織和器官。根據(jù)對(duì)免疫抑制劑的敏感性,分屬三個(gè)獨(dú)立的家族:親環(huán)蛋白PPIG、FK506結(jié)合蛋白和細(xì)蛋白。能夠加速自身折疊和體內(nèi)新生肽鏈折疊及變性蛋白質(zhì)的體外折疊,主要分布于內(nèi)質(zhì)網(wǎng)。
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