来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产成人一区二区三区影|香蕉久久久久久AV成人
Rabbit Anti-phospho-PYK2 (Tyr402)/AP Conjugated antibody (bs-3400R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3400R-AP
英文名稱1 Rabbit Anti-phospho-PYK2 (Tyr402)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的磷酸化富含脯氨酸的酪氨酸激酶2抗體
別    名 p-PTK2B(Tyr402); Pyk2(Phospho-Tyr402); PTK2B(phospho Y402); CADTK; CAK beta; CAKB antibody; CAKbeta; Calcium dependent tyrosine kinase; Calcium-dependent tyrosine kinase; Cell adhesion kinase beta; E430023O05Rik; EC 2.7.10.2; FADK 2; FADK2; FAK 2; FAK1; FAK2; Focal Adhesion Kinase 2; MGC124628; PKB; pp125FAK; Proline Rich Tyrosine Kinase 2; Proline-rich tyrosine kinase 2; Protein kinase B; Protein Tyrosine Kinase 2 Beta; PTK 2B; PTK antibody PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK 2; PYK2; RAFTK; Related adhesion focal tyrosine kinase; FAK2_HUMAN; PTK2B protein tyrosine kinase 2 beta.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 116kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Pyk2/PTK2B around the phosphorylation site of Tyr402
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.

Subunit:
Homodimer, or homooligomer. Interacts with SIRPA and SH2D3C. Interacts with ARHGAP10. Interacts with DLG4 (By similarity). Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form interacts with SRC (via SH2 domain) and SRC family members. Forms a signaling complex with EPHA1, LCK and phosphatidylinositol 3-kinase; upon activation by EFNA1. Interacts with GRB2 (via SH2 domain). Interacts with P53/TP53 and MDM2. Interacts with MYLK. Interacts with BCAR1. Interacts with PDPK1. Interacts (hypophosphorylated) with PXN. Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1. Interacts with LPXN and PTPN12.

Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus.

Tissue Specificity:
Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney (at protein level). Also expressed in spleen and lymphocytes.

Post-translational modifications:
Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS). Tyr-402 is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-402 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is important for interaction with GRB2. Phosphorylated on tyrosine residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity. Phosphorylation by MYLK promotes ITGB2 activation and is thus essential to trigger neutrophil transmigration during lung injury. Dephosphorylated by PTPN12.

DISEASE:
Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. Elevated PTK2B/PYK2 expression is seen in gliomas, hepatocellular carcinoma, lung cancer and breast cancer.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
Contains 1 FERM domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 2185 Human

Entrez Gene: 19229 Muse

Entrez Gene: 50646 Rat

Omim: 601212 Human

SwissProt: Q14289 Human

SwissProt: Q9QVP9 Mouse

SwissProt: P70600 Rat

Unigene: 491322 Human

Unigene: 21613 Mouse

Unigene: 11025 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

富含脯氨酸的酪氨酸激酶 2 (protein richtyro sinekinase 2 ,PYK2 ) ,又稱細(xì)胞粘附激酶β(cellularadhesionkinaseβ ,CAKβ)、相關(guān)粘附聚焦酪氨酸激酶(relatedadhesionfocaltyrosinekinase ,RAFTK) ,是粘著斑激酶 (focaladhesionkinase,FAK)家族的成員之一。PYK2是FAK家族的成員之一 ,是一種鈣依賴性酪氨酸激酶 ,在氨基酸序列上與FAK有 4 5 %的同源性。它的活化涉及了多條信號(hào)傳導(dǎo)通路 ,與離子通道的調(diào)節(jié)、細(xì)胞骨架的聯(lián)系及細(xì)胞增殖、凋亡密切相關(guān)。血管緊張素Ⅱ、一氧化氮可調(diào)節(jié)PYK2的活性。在神經(jīng)系統(tǒng)中高度表達(dá)的蛋白酪氨酸激酶 (Pyk2),其酪氨酸殘基因?yàn)楦鞣NG蛋白偶聯(lián)受體和胞外信號(hào)而被磷酸化,從而增加胞內(nèi)鈣離子的濃度.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
黑人巨茎和中国美女视频| 亚洲AV人人澡人人爽人人夜夜| 国产A级三级三级三级| 被喂春药蹂躏的欲仙欲死视频 | 91精品国产综合久久久久蜜臀| 67194熟妇在线观看线路1| 一区二区三区毛A片特级| 国产精品免费无遮挡无码永久视频 | av在线亚洲欧洲日产一区二区 | 婷婷五月妞干| 人妻人人澡人人添人人爽| 中文字幕人妻一区色偷偷久久| 天天干天天日| 天天做天天爱天天综合网2021| 曰本无码人妻丰满熟妇啪啪 | 97成人无码免费一区二区中文| 国产成人久久精品激情| 欧美熟妇另类久久久久久不卡| 蜜臀AV在线播放一区二区三区| 特黄AAAAAAA片免费视频| 国产av最新精品自在自线| 疯狂做受XXXX高潮欧美日本| 国产精品亚洲一区二区极品| 亚洲日韩欧美一区二区三区| H动漫在线观看| 日韩av毛片一区二区三区四区| 无码高潮少妇毛多水多水免费| 丰满的女人一区二区三区| 亚洲AV最新在线网址尤物| 波多野42部无码喷潮在线| 亚洲AV无码久久| 精品久久久久久综合日本| 国产午夜亚洲精品理论片大丰影院| 欧美日韩亚洲综合网站| 亚洲一区二区三区AV无码| 一级片淫片一区二区三区| 最近免费中文字幕大全免费版视频 | 国产女人18毛片水真多18精品| 久久久国产综合欧美日韩 | 天天爽夜夜爽夜夜爽| 国产一级二级三级在线影院|