| 產(chǎn)品編號 |
bs-3463R-RBITC |
| 英文名稱1 |
Rabbit Anti-Phospho-TH (Ser31)/RBITC Conjugated antibody
|
| 中文名稱 |
羅丹明（RBITC）標(biāo)記的磷酸化酪氨酸羥化酶抗體 |
| 別 名 |
Tyrosine Hydroxylase (Phospho-Ser31); Dystonia 14; DYT14; DYT5b; EC 1.14.16.2; OTTHUMP00000011225; OTTHUMP00000011226; ple; Protein Pale; TH; The; TY3H_RAT; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 產(chǎn)品類型 |
磷酸化抗體 |
| 研究領(lǐng)域 |
腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 內(nèi)分泌病 細(xì)胞類型標(biāo)志物 新陳代謝 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
(predicted: Mouse, Rat, )
|
| 產(chǎn)品應(yīng)用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
56kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthesised phosphopeptide derived from rat TH around the phosphorylation site of Ser31 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.
Function:
Plays an important role in the physiology of adrenergic neurons.
Subunit:
Homotetramer.
Subcellular Location:
Mainly expressed in the brain and adrenal glands.
Post-translational modifications:
In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation.
Similarity:
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Database links:
Entrez Gene: 7054 Human
Entrez Gene: 21823 Mouse
Entrez Gene: 25085 Rat
Omim: 191290 Human
SwissProt: P07101 Human
SwissProt: P24529 Mouse
SwissProt: P04177 Rat
Unigene: 435609 Human
Unigene: 1292 Mouse
Unigene: 11082 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神經(jīng)細(xì)胞標(biāo)志物
酪氨酸羥化酶（TH）是兒茶酚胺類神經(jīng)遞質(zhì)即多巴胺、去甲腎上腺素、腎上腺素生物合成過程所需的限速酶，它以四氫生物喋呤啶(BH4)為輔酶，催化酪氨酸的羥化而生成多巴(DOPA)。
已知在患帕金森病(Parkinson disease,PD)時，腦內(nèi)多巴胺(dopamine,DA)的減少與此酶活性低下有關(guān)。因此對PD模型動物來說，若將TH基因植入腦內(nèi)，便可以提高腦內(nèi)DA水平而達(dá)到基因治療目的。
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