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Rabbit Anti-Matrin 3/Cy5.5 Conjugated antibody (bs-5141R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5141R-Cy5.5
英文名稱1 Rabbit Anti-Matrin 3/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標(biāo)記的核基質(zhì)蛋白3抗體
別    名 MATR3; Matrin3; Matrin-3; KIAA0723; Matr3; MATR3_HUMAN; MPD2; VCPDM.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Matrin 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Matrin 3 (MATR 3) is an internal nuclear matrix protein that may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer MATR 3 may play a role in nuclear retention of defective RNAs. MATR3 forms part of complex consisting of SFPQ, NONO and MATR3. The protein contains 1 matrin type zinc finger and 2 RRM (RNA recognition motif) domains. Two transcript variants encoding the same protein have been identified for this gene.

Function:
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.

Subunit:
Part of complex consisting of SFPQ, NONO and MATR3. Interacts with EIF2C1 and EIF2C2.

Subcellular Location:
Nucleus matrix.

DISEASE:
Defects in MATR3 are the cause of myopathy distal type 2 (MPD2) [MIM:606070]; also called vocal cord and pharyngeal dysfunction with distal myopathy (VCPDM). MPD2 is a muscular disorder characterized by distal weakness, with onset in hands and feet, associated with vocal cord and pharyngeal weakness causing a nasal voice and swallowing disorders.

Similarity:
Contains 1 matrin-type zinc finger.
Contains 2 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 9782 Human

Entrez Gene: 17184 Mouse

Entrez Gene: 29150 Rat

Omim: 164015 Human

SwissProt: P43243 Human

SwissProt: Q8K310 Mouse

SwissProt: P43244 Rat

Unigene: 268939 Human

Unigene: 595110 Human

Unigene: 215034 Mouse

Unigene: 482118 Mouse

Unigene: 29774 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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