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Rabbit Anti-PCNP/BF647 Conjugated antibody (bs-6392R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6392R-BF647
英文名稱1 Rabbit Anti-PCNP/BF647 Conjugated antibody
中文名稱 BF647標記的PEST含核蛋白抗體
別    名 PCNP; PCNP_HUMAN; PEST containing nuclear protein; PEST proteolytic signal containing nuclear protein; PEST proteolytic signal-containing nuclear protein; PEST-containing nuclear protein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  染色質和核信號  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PCNP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
PCNP is a novel 178 amino acid nuclear protein implied to play a role in cell cycle regulation and tumorigenesis. PCNP is ubiquitinated post-translationally by NIRF (Np95/ICBP90-like RING finger protein), a ubiquitin ligase. Existing as three isoforms produced by alternative splicing events, PCNP is encoded by a gene mapping to human chromosome 3q12.3. Chromosome 3 houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3

Function:
May be involved in cell cycle regulation.

Subunit:
Interacts with UHRF2/NIRF.

Post-translational modifications:
Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.

Database links:

Entrez Gene: 57092 Human

Entrez Gene: 76302 Mouse

Entrez Gene: 288165 Rat

SwissProt: Q8WW12 Human

SwissProt: Q6P8I4 Mouse

SwissProt: Q7TP40 Rat

Unigene: 275865 Human

Unigene: 202642 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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