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Rabbit Anti-DLL3/BF488 Conjugated antibody (bs-7860R-BF488)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@73327.net
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-7860R-BF488
英文名稱1 Rabbit Anti-DLL3/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的Notch信號(hào)通路Delta樣配體3抗體
別    名 Delta Drosophila like 3; Delta like 3 Drosophila; Delta like 3 homolog Drosophila; Delta like 3 protein; Delta like protein 3 precursor; Delta3; Drosophila Delta homolog 3; SCDO1; Spondylocostal dysostosis autosomal recessive.DLL3_HUMAN  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  細(xì)胞分化  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DLL3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Delta-like 3 (DLL3) is a transmembrane Delta-like protein that inhibits primary neurogenesis. It may be required to divert neurons along a specific differentiation pathway and plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 is one of five DSL proteins that bind to the Notch receptor and activates Notch signaling.

Function:
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

Subunit:
Can bind and activate Notch-1 or another Notch receptor (Probable).

Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).

Tissue Specificity:
Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis.

Post-translational modifications:
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

DISEASE:
Note=A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities.

Similarity:
Contains 1 DSL domain.
Contains 6 EGF-like domains.

Database links:

Entrez Gene: 505993 Cow

Entrez Gene: 10683 Human

Entrez Gene: 100520433 Pig

Omim: 602768 Human

SwissProt: Q9NYJ7 Human

Unigene: 127792 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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