来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产后入清纯学生妹|爆乳熟妇乱操
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-NIPA/BF488 Conjugated antibody (bs-8363R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-8363R-BF488
英文名稱1 Rabbit Anti-NIPA/BF488 Conjugated antibody
中文名稱 BF488標記的間變性淋巴瘤激酶核相互作用伴侶蛋白抗體
別    名 hNIPA; Nuclear interacting partner of ALK; Nuclear interacting partner of anaplastic lymphoma kinase; ZC3HC1; Zinc finger C3HC type containing 1; NIPA_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  染色質(zhì)和核信號  信號轉(zhuǎn)導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIPA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. Nuclear cyclin B1 is a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle.

Function:
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Subunit:
Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1.

Subcellular Location:
Nuclear

Tissue Specificity:
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.

Post-translational modifications:
Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.

Similarity:
Contains 1 C3HC-type zinc finger.

Database links:

Entrez Gene: 51530 Human

Entrez Gene: 232679 Mouse

Entrez Gene: 296957 Rat

SwissProt: Q86WB0 Human

SwissProt: Q80YV2 Mouse

Unigene: 194157 Human

Unigene: 29780 Mouse

Unigene: 474686 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
日本一区二区三区视频| 久久久久久久久久久艹| 欧美黑人粗暴多交高潮水最多 | 成人国产亚洲精品A区天堂蜜臀 | 色哟哟网站入口在线观看视频| 挺进邻居丰满少妇的身体| 欧美日韩中文字幕亚洲视频一区二区| 99久久成人国产精品| 韩国三级HD中文字幕| 三级三级久久三级久久18| 色窝窝无码一区二区三区| 国产精品视频你懂的| 免费播放片Ⅴ免费人成视频| 精品国产911在线观看| 天堂va欧美ⅴa亚洲va在线| 日本强好片久久久久久AAA| 精品亚洲不卡一区二区| 亚洲日韩免费成人AV| 中文字幕AV久久一区二区| 精品无码黑人又粗又大又长| 国产三级久久久精品麻豆三级 | 91精品国产免费久久国语性色| 精品无码一区二区三区| 少妇精品无码一区二区三区| 日韩欧美一区二区在线不卡| 国产精品无码一本二本三本色| 日本高清一区二区三区高清| 欧美 日韩 综合 无码 专区| 丁香花在线观看免费观看图片 | 日本JAPANESE熟睡人妻| 中文字幕女优在线观看| 97人人模人人爽人人少妇| 99精品久久99久久久| 无码国产伦一区二区三区视频| 国产精品99精品一区二区三区∴| 无码性午夜视频在线观看| 小伙子自慰自慰自慰出了积液| japanesexxxx极品少妇| 亚洲中文字幕久久精品无码喷水| 狠狠躁日日躁夜夜躁2022麻豆| 小浪货腿张开水好多呀H|