来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
最新日本欧美一区二区|国产精品免费久久蜜色av
Rabbit Anti-NF-H/Cy5.5 Conjugated antibody (bs-0708R-Cy5.5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@73327.net
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0708R-Cy5.5
英文名稱1 Rabbit Anti-NF-H/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標(biāo)記的高分子量神經(jīng)絲蛋白抗體
別    名 Neurofilament 200; 200 kDa neurofilament protein; 200 kD Neurofilament Heavy; NEFH; NEFH; NF200; NF-200; Neurofilament H; Neurofilament heavy polypeptide 200kD; Neurofilament heavy polypeptide 200kDa; Neurofilament heavy polypeptide; Neurofilament triplet H protein; Neurofilament triplet H protein; Hypophosphorylated Neurofilament H; NF H; NFH; NFH_HUMAN; KIAA0845.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 118kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NF-H
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. When visualised using an electron microscope, neurofilaments appear as 10nm diameter fibres of indeterminate length that generally have fine wispy protrusions from their sides. They are particularly abundant in axons of large projection neurons. They probably function to provide structural support for neurons and their synapses and to support the large axon diameters required for rapid conduction of impulses down axons. Neurofilaments are composed of a mixture of subunits, which usually includes the three neurofilament triplet proteins neurofilament light (NFL), neurofilament medium (NFM) and neurofilament heavy (NFH). Neurofilaments may also include smaller amounts of peripherin, alpha internexin, nestin and in some cases vimentin. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable. Some studies have shown that levels of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal lobe dementia, and vascular dementia.

Function:
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

Post-translational modifications:
There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
Phosphorylated in the Head and Rod regions by the PKC kinase PKN1, leading to inhibit polymerization.

DISEASE:
Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 4744 Human

Entrez Gene: 380684 Mouse

Entrez Gene: 24587 Rat

Omim: 162230 Human

SwissProt: P12036 Human

SwissProt: P19246 Mouse

SwissProt: P16884 Rat

Unigene: 198760 Human

Unigene: 298283 Mouse

Unigene: 108194 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
中文字幕丰满伦子无码| 日韩av漂亮人妻中文字幕| 国产精品国色综合久久| 黄片免费看亚洲一区二区三区| 亚洲中文字幕电影网久久久| 日韩av有码中文字幕| 最新综合精品亚洲网址| 欧美熟女丝袜一区二区| 久久综合久久久久88| 亚洲精品国产精品国自产观看| 国产亚洲AV综合人人澡精品| 欧美三级伦理视频在线| 亚洲欧美一区二区三区在线| 人人肉人人肉人人揉| 上司人妻被下属侵犯HD| 欧美变态口味重另类在线视频| 亚洲无线码一区二区三区| 欧美人体大胆瓣开下部自慰| 丰满老熟好大BBB| 久久精品视频在线观看6| 欧美最猛黑人XXXX黑人猛交| 公交车上~嗯啊被高潮| 欧美日本一区二区a人| 少妇愉情理伦片高潮日本| 国产你懂得在线| 妈妈的朋友在线播放| 日日噜噜噜夜夜爽爽狠狠| JAPANESEHD熟女熟妇伦| 性XXXXX大片免费视频| 午夜视频试看3分钟| 国产色婷婷综合久久久久| 亚洲熟女综合色一区二区三区| 人人妻人人澡大香蕉| 天天摸夜夜添夜夜无码| WWW亚洲精品少妇裸乳一区二区| 亚洲国产精品1区2区| 亚洲欧洲日本一区精品| 少妇荡乳情欲办公室456视频 | 麻豆人妻少妇精品无码专区| 亚洲中文久久精品无码| 国内免费精品自在自线|