来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  人才招聘  關于我們  聯(lián)系我們
久久久久亚洲AV无码专区体验|亚洲AV无码一区二区一二区|欧美成人在线视频
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-BTRC2/Gold Conjugated antibody (bs-8387R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術支持:techsupport@73327.net
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-8387R-Gold
英文名稱1 Rabbit Anti-BTRC2/Gold Conjugated antibody
中文名稱 膠體金標記的BTRC2蛋白抗體
別    名 beta Transducin Repeat Containing Protein 2; BTRC2; BTRCP2; F-box and WD-40 Domain Protein 1B; F-box Protein FBW1B; FBW1B; FBXW1B; FBW1B_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  免疫學  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Zebrafish, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BTRC2/beta TRCP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Beta TRCP2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Subunit:
Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer. Interacts with BTRC, BST2, PER1, RCAN1 and USP47. Interacts with phosphorylated ubiquitination substrate PER2 (By similarity). Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. Interacts with TRIM21.

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Contains 1 F-box domain.
Contains 7 WD repeats.

Database links:
UniProtKB/Swiss-Prot: Q9UKB1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.73327.net 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
激情中文字幕人妻久久| 国产精品一区二区太大| 日本影院中文字幕不卡一区| 被多个男人调教奶头玩奶头| 久久久久久亚洲精品中文字幕熟女| 亚洲乱码国产乱码精品精| 亚洲性无码一区二区三区| 91人人澡人人妻人人澡| AV下页| 亚洲AV无码乱码国产精品久久| 亚洲欧美日韩国产综合v| 色一情一区二区三区四区| 免费国产裸体美女视频全黄| 精品无人区一区二区三区| 日韩殴美精品一区二区| 色偷偷888欧美精品久久久| 一区二区三区日本在线观看| 久久精品国产亚洲7777| 99久久人妻精品免费二区| 亚洲日韩免费成人AV| 波多野结衣中文字幕无码| 最新日一区二区不卡视频 | 中文精品久久久久人妻不卡| 欧美一区二区爽大粗| 午夜av一区二区三区中文字幕| 大SAO奶涨奶头痒快来吃| 大陆熟妇丰满多毛XXXX| 精品一区二区三区在线视频| 午夜不卡AV免费| 亚洲人成免费观看网站| 久久久国产欧美日韩| 女公务员人妻呻吟求饶| 变态另类第| 国产成人无码AA精品一区| 亚洲国产一区二区三区中文字幕| 国产三级久久精品1080p| 日韩av一区二区在线播放| 精品黑人一区二区三区| 精品无码国产自产拍在线观看蜜| 人人妻人人添人人爽欧美一区| 欧美成人一区二区三区|