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Rabbit Anti-Neuropilin 1/APC Conjugated antibody (bs-0693R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0693R-APC
英文名稱1 Rabbit Anti-Neuropilin 1/APC Conjugated antibody
中文名稱 APC標記的神經(jīng)纖毛蛋白1抗體
別    名 Neuropilin-1; NRP-1; Neuropilin1; Neuropilin 1; BDCA4; CD 304; CD304; DKFZp686A03134; DKFZp781F1414; NEL like protein 1; Nel related protein 1; Neuropilin1; Neuropilin 1; Neuropilin1 transmembrane receptor; NP1; NRP 1; NRP; NRP1; OTTHUMP00000020818; OTTHUMP00000020820; OTTHUMP00000020821; Vascular endothelial cell growth factor 165 receptor; VEGF165R; A5 protein; BLOOD DENDRITIC CELL ANTIGEN 4; NRP1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 免疫學  神經(jīng)生物學  生長因子和激素  細胞膜受體  內(nèi)皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Chicken, Sheep, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human neuropilin-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subunit:
Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Similarity:
Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.

Database links:
Entrez Gene: 8829 Human

Entrez Gene: 18186 Mouse

Entrez Gene: 246331 Rat

Omim: 602069 Human

SwissProt: O14786 Human

SwissProt: Q5T7F3 Human

SwissProt: P97333 Mouse

SwissProt: Q6PAR3 Mouse

SwissProt: Q9QWJ9 Rat

Unigene: 131704 Human

Unigene: 653996 Human

Unigene: 271745 Mouse

Unigene: 10815 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD304是一種神經(jīng)元受體,被認為表達于眾多的非造血細胞上,包括神經(jīng)元、內(nèi)皮細胞和腫瘤細胞。在體外單核細胞和造血前體細胞衍生的CD1a+樹突狀細胞是CD304(BDCA-4/Neuropilin-1)。
與CD303(BDCA-2)一樣,CD304(BDCA-4)抗原特異性地表達于人血液和骨髓中的漿樣樹突狀細胞。與CD303(BDCA-2)不同的是,CD304(BDCA-4)在培養(yǎng)的漿樣樹突狀細胞上表達上調(diào),同時在培養(yǎng)的髓系細胞能被誘導表達。在感染的扁桃體中,CD304(BDCA-4)不僅表達于漿樣樹突狀細胞,而且在其它細胞上也能檢測到,如初級濾泡B輔助性記憶T細胞。
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