| 產(chǎn)品編號 | bs-1095R-BF488 |
| 英文名稱1 | Rabbit Anti-Orexin receptor 1+2/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的丘腦分泌素受體1+2/食欲素受體1+2抗體 |
| 別 名 | Orexin Receptor 1 and 2; Orexin receptor 1 + 2; Orexin Receptor 2; HCRTR 1; HCRTR1; Hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1r; OX1R_HUMAN; Hcrtr2; Hypocretin (orexin) receptor 2; Hypocretin receptor 2; Hypocretin receptor type 2; Orexin receptor 2; Orexin receptor type 2; Ox-2-R; Ox2-R; Ox2r; OX2R_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 通道蛋白 細胞膜受體 內(nèi)分泌病 G蛋白偶聯(lián)受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Orexin receptor 1/2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009] Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 3061 Human Entrez Gene: 230777 Mouse Omim: 602392 Human SwissProt: O43613 Human SwissProt: P58307 Mouse Unigene: 388226 Human Unigene: 246595 Mouse Unigene: 88262 Rat Entrez Gene: 3062 Human Entrez Gene: 387285 Mouse Omim: 602393 Human SwissProt: O43614 Human SwissProt: P58308 Mouse Unigene: 151624 Human Unigene: 699147 Human Unigene: 335300 Mouse Unigene: 9893 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 食欲素受體(OXR)Orexin receptor—是一種G蛋白偶合受體. 下丘腦是調(diào)節(jié)飲食及能量平衡的中樞.學(xué)者認(rèn)為：在下丘腦可促進食欲且來源于同一前體的兩種新神經(jīng)肽:食欲素A和B,它們可激活兩種密切相關(guān)且與G蛋白偶聯(lián)的細胞表面受體(OX1R,OX2R).含Orexin的神經(jīng)細胞在下丘腦腹外側(cè)呈對稱的不連貫分布. 在飲食反饋調(diào)節(jié)中具有重要作用.食欲素與其它影響進食的神經(jīng)肽之間存在錯綜復(fù)雜的關(guān)系.它在增加攝食、飲水、調(diào)節(jié)睡眠覺醒周期、生殖、體溫、血壓和感覺等方面有廣泛作用. |
