| 產(chǎn)品編號(hào) | bs-0280R-BF594 |
| 英文名稱1 | Rabbit Anti-PLGF/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的胎盤生長因子抗體 |
| 別 名 | Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 生長因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse PLGF |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Subunit: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Subcellular Location: Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. Tissue Specificity: While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. Post-translational modifications: N-glycosylated. Similarity: Belongs to the PDGF/VEGF growth factor family. Database links: Entrez Gene: 5228 Human Entrez Gene: 18654 Mouse Omim: 601121 Human SwissProt: P49763 Human SwissProt: P49764 Mouse Unigene: 252820 Human Unigene: 4809 Mouse Unigene: 6960 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PLGF胎盤生長因子是血管生長因子家族成員之一（又稱：胎盤型血管內(nèi)皮細(xì)胞生長因子），是動(dòng)脈粥樣硬化斑塊不穩(wěn)定的主要炎性激活物，因此它可作為ACS患者風(fēng)險(xiǎn)預(yù)測(cè)的生物學(xué)標(biāo)志物.尿胎盤生長因子水平可預(yù)測(cè)先兆子癇危險(xiǎn).研究人員發(fā)現(xiàn)，在疾病發(fā)作前的6到8周，先兆子癇患者尿液中的胎盤生長因子水平急劇下降,這種新的尿檢方法使提前1到2個(gè)月預(yù)測(cè)先兆子癇成為可能。亦有研究人員正在從事胎盤生長因子與肺氣腫，胃癌，腸癌等方面的研究。 |
