来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
女人做几次就不紧了|日韩av毛片一区二区三区四区
Rabbit Anti-TIMP-2/PE-Cy5.5 Conjugated antibody (bs-0416R-PE-Cy5.5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@73327.net
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0416R-PE-Cy5.5
英文名稱1 Rabbit Anti-TIMP-2/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的金屬蛋白酶組織抑制因子-2抗體
別    名 Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長(zhǎng)因子和激素  合成與降解  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIMP-2 (125-160aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].

Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Subunit:
Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

Subcellular Location:
Secreted.

Post-translational modifications:
The activity of TIMP2 is dependent on the presence of disulfide bonds.

Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

Database links:

Entrez Gene: 282093 Cow

Entrez Gene: 100135629 Guinea pig

Entrez Gene: 7077 Human

Entrez Gene: 21858 Mouse

Entrez Gene: 100008689 Rabbit

Entrez Gene: 29543 Rat

Omim: 188825 Human

SwissProt: P16368 Cow

SwissProt: Q9WUC6 Guinea pig

SwissProt: P16035 Human

SwissProt: P25785 Mouse

SwissProt: Q9TRZ7 Rabbit

SwissProt: P30121 Rat

Unigene: 633514 Human

Unigene: 206505 Mouse

Unigene: 10161 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
TIMP-2與TIMP-1一樣是基質(zhì)金屬蛋白酶的抑制酶,其功能與MMP相反,能抑制腫瘤細(xì)胞的浸潤(rùn)和轉(zhuǎn)移,主要用于各種惡性腫瘤如乳腺癌等的研究。TIMP-2又稱為CSC-21K,是一種21-24kDa的糖蛋白,在多種組織細(xì)胞中表達(dá),它可以和MMPs家族成員以共價(jià)鍵方式形成復(fù)合物,從而發(fā)揮其抑制作用。在正常生理?xiàng)l件下,MMPs和TIMPs之間的平衡狀態(tài)是維持細(xì)胞外基質(zhì)正常狀態(tài)所必需的,一旦它們之間的比例失調(diào),就會(huì)造成一系列的病理狀態(tài)。
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
久久精品一区二区三区综合| 伊人久久精品一区二区三区| 人人添人人妻人人爽夜欢视AV| 欧美 变态 另类 人妖| 熟女久久久精品视频| 日韩人妻无码中文字幕| 少妇BBW搡BBBB搡BBBB| 精品国产亚洲av激情五月| 乳尖乱颤娇喘连连A片在线观看| 久久亚洲精品人成综合网| 999国产精品999久久久久久| 无码人妻精品一区二区三区东京热 | 天堂va欧美ⅴa亚洲va在线| 中文字日产幕码三区的做法大全| 中文字幕久久熟女蜜桃| 99久久精品免费视频观看| 在线手机av手机版| 日本护士野外XXXHD| 女人扒开屁股爽桶30分钟| 久9精品国产自在现线| 人人妻人人玩人人澡人人爽免费| 日本一区二区三区夜视频| 日韩黄色极品美女污污视频网站 | 国产精品99久久免费观看| 超碰人人澡人摸人人添| 国产精品亚欧美一区二区三区| 精品亚洲成A人无码成A在线观看 | 日日摸夜夜添夜夜添高潮喷水| 97精品一区二区视频在线观看| 久久国产欧美一区二区三级精品| 歪歪漫画网站页面入口弹窗秋蝉| 亚洲精久久久久久久 | 中文字幕高清一区二区三区| 精品无码久久久久久国产| 久久乐亚洲国产精品综合| 18禁免费高清啪啪网站| 无码人妻丰满熟妇区五十路百 | 免费无码国产欧美久久18| 国产精品色情国产三级金瓶双艳| 日本人妻中文字幕在线一区| 亚洲av午夜精品一区二区三区|