| 產(chǎn)品編號 | bs-9721R-BF488 |
| 英文名稱1 | Rabbit Anti-FEZ1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的腦胚胎鋅指樣蛋白1抗體 |
| 別 名 | Fasciculation and elongation protein zeta 1; Fasciculation and elongation protein zeta-1; Fez 1; Fez; Fez-like zinc finger protein; FEZ1; FEZ1_HUMAN; Fezl; Forebrain embryonic zinc-finger like protein; Zpf312; Zygin 1; Zygin I; Zygin-1; Zygin1; ZyginI. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細胞周期蛋白 細胞分化 鋅指蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FEZ1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase. Function: May be involved in axonal outgrowth as component of thenetwork of molecules that regulate cellular morphology and axonguidance machinery. Able to restore partial locomotion and axonalfasciculation to C.elegans unc-76 mutants in germlinetransformation experiments. May participate in the transport ofmitochondria and other cargos along microtubules. Subunit: Homodimer; difulfide-linked. May form heterodimers withFEZ2. Interacts with the NH2-terminal variable region (V1) of PKCzeta and weakly with that of PKC epsilon (By similarity). Interactswith UBE4B. Interacts with SAP30L. Interacts with SCOC and ULK1;SCOC interferes with ULK1-binding to FEZ1. Directly interacts withSCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAGduring amino acid starvation. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Cellmembrane (By similarity). Note=Co-localizes with both, alpha- andgamma-tubulin. Translocated from the plasma membrane to thecytoplasm by activation of the PKC zeta (By similarity). Tissue Specificity: Mainly expressed in brain. Post-translational modifications: Phosphorylated by protein kinase C zeta; which enhancesinteraction with UBE4B and polyubiquitination. Polyubiquitinated in a UBE4B-dependent manner; which does notlead to proteasomal degradation and may be important for neurogenicactivity. Polyubiquitin linkage seems to be mainly through Lys-26. Similarity: Belongs to the zygin family. Database links: Entrez Gene: 9638 Human Entrez Gene: 235180 Mouse Omim: 604825 Human SwissProt: Q99689 Human SwissProt: Q8K0X8 Mouse Unigene: 224008 Human Unigene: 5264 Mouse Unigene: 5468 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
