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Rabbit Anti-SFRP4/Gold Conjugated antibody (bs-1331R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-1331R-Gold
英文名稱1 Rabbit Anti-SFRP4/Gold Conjugated antibody
中文名稱 膠體金標記的子宮內膜抗體
別    名 sFRP-4; Secreted frizzled-related protein 4; Frizzled protein, human endometrium; FrpHE; SFRP4; SFRP4_MOUSE; SFRP4_HUMAN; FRPHE.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 免疫學  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human sFRP-4 C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. [SUBCELLULAR LOCATION] Secreted. Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Belongs to the secreted frizzled-related protein (sFRP) family.

Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung.

Similarity:
Belongs to the secreted frizzled-related protein (sFRP) family.
Contains 1 FZ (frizzled) domain.
Contains 1 NTR domain.

Database links:

Entrez Gene: 6424 Human

Entrez Gene: 20379 Mouse

Entrez Gene: 89803 Rat

Omim: 606570 Human

SwissProt: Q6FHJ7 Human

SwissProt: Q9Z1N6 Mouse

SwissProt: Q9JLS4 Rat

Unigene: 658169 Human

Unigene: 42095 Mouse

Unigene: 10788 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

抗子宮內膜抗體屬于自身抗體,在正常育齡婦女中也可以檢測到,但在不孕癥人群中,特別是患有子宮內膜異位癥的婦女中更多見。
正常機體具有自身免疫調節(jié)功能,產生極弱的自身抗體,幫助清除體內衰老變性的自身成分,但由于某種原因導致免疫系統(tǒng)對自身組織產生過度免疫應答,則會發(fā)生過強的一系列免疫反應,致使所侵及的組織免疫活性細胞增多,免疫復合物沉積,而導致功能改變。當這種抗子宮內膜抗體由于反復刺激而大量產生達到一定的含量時,可與自身的子宮內膜組織發(fā)生抗原抗體結合反應,并激活免疫系統(tǒng)引起損傷性效應,造成子宮內膜組織細胞生化代謝及生理功能的損害,干擾和妨礙精卵結合,受精卵的著床和胚囊的發(fā)育而導致不孕或流產。
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