来一水AV@lysav|亚洲AV无码片VR一区二区三区 |国产亚洲精久久久久久无码|视色4se成人午夜精品久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
久久精品国产精品亚洲色婷婷|日韩亚洲欧美久久久
Rabbit Anti-G3BP1/Biotin Conjugated antibody (bs-4111R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@73327.net
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@73327.net
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4111R-Bio
英文名稱1 Rabbit Anti-G3BP1/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的Ras GTP酶活化蛋白結(jié)合蛋白1抗體
別    名 ATP dependent DNA helicase VIII; G3BP; G3BP1; GAP binding protein; GAP SH3 domain binding protein 1; HDH VIII; MGC111040; Ras GTPase activating protein binding protein 1; Ras GTPase activating protein SH3 domain binding protein; RasGAP associated endoribonuclease G3BP.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  染色質(zhì)和核信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G3BP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].

Function:
May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.

Subunit:
Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells. No interaction in quiescent cells Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity). Interacts with USP10, and may regulate it. Forms homodimers and oligomers.

Subcellular Location:
Cytoplasm. Cytoplasm, cytosol. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells. Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts. Hypophosphorylation leads to a decrease in endoribonuclease activity (By similarity). RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization.
Arg-435 is dimethylated, probably to asymmetric dimethylarginine.

Similarity:
Contains 1 NTF2 domain.
Contains 1 RRM (RNA recognition motif) domain.

Database links:

Entrez Gene: 10146 Human

Omim: 608431 Human

SwissProt: Q13283 Human

Unigene: 587054 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.73327.net 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲色偷偷综合亚洲AV伊人 | 国产V综合V亚洲欧美久久| 国产一区二区久久久久久久免费 | 亚洲国产精品欧美日韩久久久| 亚洲乱妇亚洲乱妇XINGLU| 美日韩不卡av免费一区二区 | 老司机午夜福利视频| 国产日韩AV在线播放| 狠狠色综合7777久夜色撩人 | 丝袜美腿一区二区三区| 少妇特大毛BBW | JIZZ日本| 亚洲九九视频一区二区三区| 日韩精品一区二区视频在线观看| 精品99视频在线观看| 国产99久久久国产精品免费看| 性做爰高清视频在线观看视频| 18VIDEOSEX性欧美69| 三级三码视频在线播放| 人妻巨大乳一二三区| 国产原创熟女视频99| 精品高清一区二区视频线欧美| 网站你懂得| 小婕子的第一次好紧| 无码精品人妻一区二区三区AV| 久久久久久久做爰片无码| 体验区试看120秒啪啪免费| 一本久道综合色婷婷五月| 欧美巨鞭大战丰满少妇| 亚洲精品无码乱码成人| 疯狂的肥岳交换130部小短片| 欧美亚洲国产第一精品久久| 中文字幕色AV一区二区三区| 国产乱人对白A片麻豆| 真实国产老熟女无套中出| 亚洲AV无码片VR一区二区三区| 在线观看的av网站| 国产乱一区二区三区夜夜爽| 亚洲色婷婷一区二区三区| 精品人妻无码一区二区三区4| 亚洲AV无码乱码国产精品FC2|